Neuropsychological evidence of multi-domain network hubs in the human thalamus

Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framewor...

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Autores principales:	Kai Hwang, James M Shine, Joel Bruss, Daniel Tranel, Aaron Boes
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	thalamus functional connectivity hub Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b130d214b9841859fca6bec75324965
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spelling	oai:doaj.org-article:8b130d214b9841859fca6bec753249652021-11-29T12:14:29ZNeuropsychological evidence of multi-domain network hubs in the human thalamus10.7554/eLife.694802050-084Xe69480https://doaj.org/article/8b130d214b9841859fca6bec753249652021-10-01T00:00:00Zhttps://elifesciences.org/articles/69480https://doaj.org/toc/2050-084XHubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition.Kai HwangJames M ShineJoel BrussDaniel TranelAaron BoeseLife Sciences Publications Ltdarticlethalamusfunctional connectivityhubMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thalamus functional connectivity hub Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	thalamus functional connectivity hub Medicine R Science Q Biology (General) QH301-705.5 Kai Hwang James M Shine Joel Bruss Daniel Tranel Aaron Boes Neuropsychological evidence of multi-domain network hubs in the human thalamus
description	Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition.
format	article
author	Kai Hwang James M Shine Joel Bruss Daniel Tranel Aaron Boes
author_facet	Kai Hwang James M Shine Joel Bruss Daniel Tranel Aaron Boes
author_sort	Kai Hwang
title	Neuropsychological evidence of multi-domain network hubs in the human thalamus
title_short	Neuropsychological evidence of multi-domain network hubs in the human thalamus
title_full	Neuropsychological evidence of multi-domain network hubs in the human thalamus
title_fullStr	Neuropsychological evidence of multi-domain network hubs in the human thalamus
title_full_unstemmed	Neuropsychological evidence of multi-domain network hubs in the human thalamus
title_sort	neuropsychological evidence of multi-domain network hubs in the human thalamus
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/8b130d214b9841859fca6bec75324965
work_keys_str_mv	AT kaihwang neuropsychologicalevidenceofmultidomainnetworkhubsinthehumanthalamus AT jamesmshine neuropsychologicalevidenceofmultidomainnetworkhubsinthehumanthalamus AT joelbruss neuropsychologicalevidenceofmultidomainnetworkhubsinthehumanthalamus AT danieltranel neuropsychologicalevidenceofmultidomainnetworkhubsinthehumanthalamus AT aaronboes neuropsychologicalevidenceofmultidomainnetworkhubsinthehumanthalamus
_version_	1718407413530361856

Neuropsychological evidence of multi-domain network hubs in the human thalamus

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