Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat

Hartati Purbo Dharmadji, Oki Suwarsa, Endang Sutedja, Miranti Pangastuti, Hendra Gunawan, Kristina Makarti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Miranti PangastutiDepartment of Dermatology...

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Autores principales:	Dharmadji HP, Suwarsa O, Sutedja E, Pangastuti M, Gunawan H, Makarti K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	erythema induratum of bazin mycobacterium tuberculosis panniculitis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8b15b9adad2141bc82b468af6640f26a
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spelling	oai:doaj.org-article:8b15b9adad2141bc82b468af6640f26a2021-11-16T18:47:50ZErythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat1179-142Xhttps://doaj.org/article/8b15b9adad2141bc82b468af6640f26a2021-11-01T00:00:00Zhttps://www.dovepress.com/erythema-induratum-of-bazin-accompanied-by-atrophy-of-the-subcutaneous-peer-reviewed-fulltext-article-IMCRJhttps://doaj.org/toc/1179-142XHartati Purbo Dharmadji, Oki Suwarsa, Endang Sutedja, Miranti Pangastuti, Hendra Gunawan, Kristina Makarti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Miranti PangastutiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Jl. Pasteur 38, Bandung, 40161, West Java, IndonesiaTel +6281223114874Email pangastuti.miranti@gmail.comAbstract: Erythema induratum of Bazin (EIB) is a predominantly lobular panniculitis with or without vasculitis due to Mycobacterium tuberculosis (MTB) infection. Atrophic scars may remain after EIB was healed. Rare cases of EIB showing sharp skin depression may mimic deep morphea and lupus profundus. A rare case of EIB was reported in a 35-year-old female with slightly tender erythematous-violaceous nodules and hyperpigmented depressed scars on both lower legs, resulting in asymmetrical lower leg shape. Histopathological examination showed lobular panniculitis without vasculitis and granulomatous inflammation consisted of caseous necrosis, epithelioid cells, and multinucleated giant cells. Polymerase chain reaction (PCR) from skin biopsy revealed deoxyribonucleic acid (DNA) of MTB. Tuberculin skin test (TST) was positive with a 20-mm induration, and nuclear 99mTc-ethambutol scintigraphy was positive for tuberculosis infection in one-third distal portion of the left lower leg. Clinical improvements were shown after 6 months of antituberculosis therapy. EIB must be considered in patient with erythematous-violaceous nodules on lower leg, especially in endemic areas of tuberculosis infection since diagnosis can be difficult and occasionally, deceptive.Keywords: erythema induratum of Bazin, Mycobacterium tuberculosis, panniculitisDharmadji HPSuwarsa OSutedja EPangastuti MGunawan HMakarti KDove Medical Pressarticleerythema induratum of bazinmycobacterium tuberculosispanniculitisMedicine (General)R5-920ENInternational Medical Case Reports Journal, Vol Volume 14, Pp 777-781 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	erythema induratum of bazin mycobacterium tuberculosis panniculitis Medicine (General) R5-920
spellingShingle	erythema induratum of bazin mycobacterium tuberculosis panniculitis Medicine (General) R5-920 Dharmadji HP Suwarsa O Sutedja E Pangastuti M Gunawan H Makarti K Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
description	Hartati Purbo Dharmadji, Oki Suwarsa, Endang Sutedja, Miranti Pangastuti, Hendra Gunawan, Kristina Makarti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Miranti PangastutiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Jl. Pasteur 38, Bandung, 40161, West Java, IndonesiaTel +6281223114874Email pangastuti.miranti@gmail.comAbstract: Erythema induratum of Bazin (EIB) is a predominantly lobular panniculitis with or without vasculitis due to Mycobacterium tuberculosis (MTB) infection. Atrophic scars may remain after EIB was healed. Rare cases of EIB showing sharp skin depression may mimic deep morphea and lupus profundus. A rare case of EIB was reported in a 35-year-old female with slightly tender erythematous-violaceous nodules and hyperpigmented depressed scars on both lower legs, resulting in asymmetrical lower leg shape. Histopathological examination showed lobular panniculitis without vasculitis and granulomatous inflammation consisted of caseous necrosis, epithelioid cells, and multinucleated giant cells. Polymerase chain reaction (PCR) from skin biopsy revealed deoxyribonucleic acid (DNA) of MTB. Tuberculin skin test (TST) was positive with a 20-mm induration, and nuclear 99mTc-ethambutol scintigraphy was positive for tuberculosis infection in one-third distal portion of the left lower leg. Clinical improvements were shown after 6 months of antituberculosis therapy. EIB must be considered in patient with erythematous-violaceous nodules on lower leg, especially in endemic areas of tuberculosis infection since diagnosis can be difficult and occasionally, deceptive.Keywords: erythema induratum of Bazin, Mycobacterium tuberculosis, panniculitis
format	article
author	Dharmadji HP Suwarsa O Sutedja E Pangastuti M Gunawan H Makarti K
author_facet	Dharmadji HP Suwarsa O Sutedja E Pangastuti M Gunawan H Makarti K
author_sort	Dharmadji HP
title	Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
title_short	Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
title_full	Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
title_fullStr	Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
title_full_unstemmed	Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat
title_sort	erythema induratum of bazin accompanied by atrophy of the subcutaneous fat
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8b15b9adad2141bc82b468af6640f26a
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Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat

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