Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyon-Xhi Tan, Jennifer A. Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G. Kelly, Kathleen M. Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L. Mordant, Kanta Subbarao, Stephen J. Kent, Adam K. Wheatley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b17f9766ef544d9a9c0b913c34a2543
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b17f9766ef544d9a9c0b913c34a2543
record_format	dspace
spelling	oai:doaj.org-article:8b17f9766ef544d9a9c0b913c34a25432021-12-02T13:34:29ZImmunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques10.1038/s41467-021-21665-82041-1723https://doaj.org/article/8b17f9766ef544d9a9c0b913c34a25432021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21665-8https://doaj.org/toc/2041-1723Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategies with S and/or RBD in mice and macaques.Hyon-Xhi TanJennifer A. JunoWen Shi LeeIsaac Barber-AxthelmHannah G. KellyKathleen M. WraggRobyn EsterbauerThakshila AmarasenaFrancesca L. MordantKanta SubbaraoStephen J. KentAdam K. WheatleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyon-Xhi Tan Jennifer A. Juno Wen Shi Lee Isaac Barber-Axthelm Hannah G. Kelly Kathleen M. Wragg Robyn Esterbauer Thakshila Amarasena Francesca L. Mordant Kanta Subbarao Stephen J. Kent Adam K. Wheatley Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
description	Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategies with S and/or RBD in mice and macaques.
format	article
author	Hyon-Xhi Tan Jennifer A. Juno Wen Shi Lee Isaac Barber-Axthelm Hannah G. Kelly Kathleen M. Wragg Robyn Esterbauer Thakshila Amarasena Francesca L. Mordant Kanta Subbarao Stephen J. Kent Adam K. Wheatley
author_facet	Hyon-Xhi Tan Jennifer A. Juno Wen Shi Lee Isaac Barber-Axthelm Hannah G. Kelly Kathleen M. Wragg Robyn Esterbauer Thakshila Amarasena Francesca L. Mordant Kanta Subbarao Stephen J. Kent Adam K. Wheatley
author_sort	Hyon-Xhi Tan
title	Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
title_short	Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
title_full	Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
title_fullStr	Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
title_full_unstemmed	Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
title_sort	immunogenicity of prime-boost protein subunit vaccine strategies against sars-cov-2 in mice and macaques
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b17f9766ef544d9a9c0b913c34a2543
work_keys_str_mv	AT hyonxhitan immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT jenniferajuno immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT wenshilee immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT isaacbarberaxthelm immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT hannahgkelly immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT kathleenmwragg immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT robynesterbauer immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT thakshilaamarasena immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT francescalmordant immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT kantasubbarao immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT stephenjkent immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques AT adamkwheatley immunogenicityofprimeboostproteinsubunitvaccinestrategiesagainstsarscov2inmiceandmacaques
_version_	1718392806672695296

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Ejemplares similares