Transition and identification of pathological states in p53 dynamics for therapeutic intervention
Abstract We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct dynamical states of p53 are observed. These states...
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Autores principales: | Amit Jangid, Md. Zubbair Malik, Ram Ramaswamy, R. K. Brojen Singh |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/8b1c7848d1d04c9482ce50d506332f2f |
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