Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.

The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs). Detection of virus triggers signalling cascades that induce transcriptio...

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Autores principales: Jamel Mankouri, Rennos Fragkoudis, Kathryn H Richards, Laura F Wetherill, Mark Harris, Alain Kohl, Richard M Elliott, Andrew Macdonald
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/8b1cdff4e5f94af59bc041f47ac7542d
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