Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma

This study aimed to evaluate the levels of eicosanoids derived from arachidonic acid (ARA) in the lungs of asthmatic rats supplemented with fish oil. The present data gives insight into the action of fish oil in asthma, related to its inability to modify the contractile capacity of tracheal smooth m...

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Autores principales:	D.T.S.Z. Miranda, A.L. Zanatta, E.A. Miles, P.C. Calder, A. Nishiyama
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Fish oil Asthma Eicosanoid Leukotriene Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/8b1ce825922a42068e40b86e9ff33924
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spelling	oai:doaj.org-article:8b1ce825922a42068e40b86e9ff339242021-12-02T05:02:38ZLeukotriene B4 limits the effectiveness of fish oil in an animal model of asthma2405-844010.1016/j.heliyon.2021.e08326https://doaj.org/article/8b1ce825922a42068e40b86e9ff339242021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024294https://doaj.org/toc/2405-8440This study aimed to evaluate the levels of eicosanoids derived from arachidonic acid (ARA) in the lungs of asthmatic rats supplemented with fish oil. The present data gives insight into the action of fish oil in asthma, related to its inability to modify the contractile capacity of tracheal smooth muscle reported previously in a model of asthma in rats. Male Wistar rats were supplemented daily with 1 g of fish oil/kg of body weight for 21 days. They were exposed to ovalbumin (OVA) after previous sensitization with OVA to induce asthma. Pulmonary levels of five eicosanoids were measured using immunoassay kits: PGE2, TXB2, LTB4, LXA4, and 8-iso PGF2α. In asthmatic rats, supplementation with fish oil resulted in lower concentrations of lung eicosanoids produced by cyclooxygenase-2 and 15-lipoxygenase: PGE2, TXB2, and LXA4, respectively. Fish oil supplementation also decreased the non-enzymatically produced eicosanoid 8-iso PGF2α. Fish oil supplementation did not affect LTB4, a metabolite of 5-lipoxygenase. The limited efficacy of fish oil supplementation in asthmatic rats is associated with a lack of action in reducing the levels of LTB4 in the lungs. Thus, fish oil differentially modulates the concentrations of eicosanoids derived from ARA via specific pathways in an animal model of asthma.D.T.S.Z. MirandaA.L. ZanattaE.A. MilesP.C. CalderA. NishiyamaElsevierarticleFish oilAsthmaEicosanoidLeukotrieneScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08326- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fish oil Asthma Eicosanoid Leukotriene Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Fish oil Asthma Eicosanoid Leukotriene Science (General) Q1-390 Social sciences (General) H1-99 D.T.S.Z. Miranda A.L. Zanatta E.A. Miles P.C. Calder A. Nishiyama Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
description	This study aimed to evaluate the levels of eicosanoids derived from arachidonic acid (ARA) in the lungs of asthmatic rats supplemented with fish oil. The present data gives insight into the action of fish oil in asthma, related to its inability to modify the contractile capacity of tracheal smooth muscle reported previously in a model of asthma in rats. Male Wistar rats were supplemented daily with 1 g of fish oil/kg of body weight for 21 days. They were exposed to ovalbumin (OVA) after previous sensitization with OVA to induce asthma. Pulmonary levels of five eicosanoids were measured using immunoassay kits: PGE2, TXB2, LTB4, LXA4, and 8-iso PGF2α. In asthmatic rats, supplementation with fish oil resulted in lower concentrations of lung eicosanoids produced by cyclooxygenase-2 and 15-lipoxygenase: PGE2, TXB2, and LXA4, respectively. Fish oil supplementation also decreased the non-enzymatically produced eicosanoid 8-iso PGF2α. Fish oil supplementation did not affect LTB4, a metabolite of 5-lipoxygenase. The limited efficacy of fish oil supplementation in asthmatic rats is associated with a lack of action in reducing the levels of LTB4 in the lungs. Thus, fish oil differentially modulates the concentrations of eicosanoids derived from ARA via specific pathways in an animal model of asthma.
format	article
author	D.T.S.Z. Miranda A.L. Zanatta E.A. Miles P.C. Calder A. Nishiyama
author_facet	D.T.S.Z. Miranda A.L. Zanatta E.A. Miles P.C. Calder A. Nishiyama
author_sort	D.T.S.Z. Miranda
title	Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
title_short	Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
title_full	Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
title_fullStr	Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
title_full_unstemmed	Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
title_sort	leukotriene b4 limits the effectiveness of fish oil in an animal model of asthma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8b1ce825922a42068e40b86e9ff33924
work_keys_str_mv	AT dtszmiranda leukotrieneb4limitstheeffectivenessoffishoilinananimalmodelofasthma AT alzanatta leukotrieneb4limitstheeffectivenessoffishoilinananimalmodelofasthma AT eamiles leukotrieneb4limitstheeffectivenessoffishoilinananimalmodelofasthma AT pccalder leukotrieneb4limitstheeffectivenessoffishoilinananimalmodelofasthma AT anishiyama leukotrieneb4limitstheeffectivenessoffishoilinananimalmodelofasthma
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Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma

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