Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases

Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TS...

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Autores principales:	Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R. Reynolds, Anthoula Lazaris, Peter Metrakos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b1df7b825274fc992efc28e02e7aa91
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spelling	oai:doaj.org-article:8b1df7b825274fc992efc28e02e7aa912021-12-02T18:50:46ZRunt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases10.1038/s42003-021-02481-82399-3642https://doaj.org/article/8b1df7b825274fc992efc28e02e7aa912021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02481-8https://doaj.org/toc/2399-3642Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TSP1 in tumor cells and TGFβ1 in the liver.Miran RadaAudrey Kapelanski-LamoureuxStephanie PetrilloSébastien TabarièsPeter SiegelAndrew R. ReynoldsAnthoula LazarisPeter MetrakosNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Miran Rada Audrey Kapelanski-Lamoureux Stephanie Petrillo Sébastien Tabariès Peter Siegel Andrew R. Reynolds Anthoula Lazaris Peter Metrakos Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
description	Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TSP1 in tumor cells and TGFβ1 in the liver.
format	article
author	Miran Rada Audrey Kapelanski-Lamoureux Stephanie Petrillo Sébastien Tabariès Peter Siegel Andrew R. Reynolds Anthoula Lazaris Peter Metrakos
author_facet	Miran Rada Audrey Kapelanski-Lamoureux Stephanie Petrillo Sébastien Tabariès Peter Siegel Andrew R. Reynolds Anthoula Lazaris Peter Metrakos
author_sort	Miran Rada
title	Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
title_short	Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
title_full	Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
title_fullStr	Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
title_full_unstemmed	Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
title_sort	runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b1df7b825274fc992efc28e02e7aa91
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Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases

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