Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases

Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TS...

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Autores principales: Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R. Reynolds, Anthoula Lazaris, Peter Metrakos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8b1df7b825274fc992efc28e02e7aa91
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