Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

The kinase mTOR controls anabolic metabolism. Here, the authors create fat-specific mTORC2 knockout mice using the Adiponectin-Cre driver and show mTORC2 signalling is important for systemic metabolic homeostasis by controlling adipocyte de novolipogenesis and glucose uptake.

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Detalles Bibliográficos
Autores principales:	Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, David A. Guertin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b210ace86684fa9b926e0715133be0a
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spelling	oai:doaj.org-article:8b210ace86684fa9b926e0715133be0a2021-12-02T15:34:58ZAdipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism10.1038/ncomms113652041-1723https://doaj.org/article/8b210ace86684fa9b926e0715133be0a2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11365https://doaj.org/toc/2041-1723The kinase mTOR controls anabolic metabolism. Here, the authors create fat-specific mTORC2 knockout mice using the Adiponectin-Cre driver and show mTORC2 signalling is important for systemic metabolic homeostasis by controlling adipocyte de novolipogenesis and glucose uptake.Yuefeng TangMartina WallaceJoan Sanchez-GurmachesWen-Yu HsiaoHuawei LiPeter L. LeeSantiago VerniaChristian M. MetalloDavid A. GuertinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuefeng Tang Martina Wallace Joan Sanchez-Gurmaches Wen-Yu Hsiao Huawei Li Peter L. Lee Santiago Vernia Christian M. Metallo David A. Guertin Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
description	The kinase mTOR controls anabolic metabolism. Here, the authors create fat-specific mTORC2 knockout mice using the Adiponectin-Cre driver and show mTORC2 signalling is important for systemic metabolic homeostasis by controlling adipocyte de novolipogenesis and glucose uptake.
format	article
author	Yuefeng Tang Martina Wallace Joan Sanchez-Gurmaches Wen-Yu Hsiao Huawei Li Peter L. Lee Santiago Vernia Christian M. Metallo David A. Guertin
author_facet	Yuefeng Tang Martina Wallace Joan Sanchez-Gurmaches Wen-Yu Hsiao Huawei Li Peter L. Lee Santiago Vernia Christian M. Metallo David A. Guertin
author_sort	Yuefeng Tang
title	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
title_short	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
title_full	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
title_fullStr	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
title_full_unstemmed	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
title_sort	adipose tissue mtorc2 regulates chrebp-driven de novo lipogenesis and hepatic glucose metabolism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8b210ace86684fa9b926e0715133be0a
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Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

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