Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock

Abstract The mechanisms underlying food anticipatory activity are still poorly understood. Here we explored the role of oxytocin (OT) and the protein c-Fos in the supraoptic nucleus (SON), medial (PVNm) and posterior (PVNp) regions of the paraventricular hypothalamic nucleus. Adult rats were assigne...

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Autores principales:	Mario Caba, Enrique Meza, Carolina Escobar, Angeles Jiménez, Mario Daniel Caba-Flores, María Luisa Moreno-Cortés, Angel I. Melo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b231caabf3d4f81ad753dc5b0f96c0b
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spelling	oai:doaj.org-article:8b231caabf3d4f81ad753dc5b0f96c0b2021-12-02T18:37:10ZOxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock10.1038/s41598-021-99266-02045-2322https://doaj.org/article/8b231caabf3d4f81ad753dc5b0f96c0b2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99266-0https://doaj.org/toc/2045-2322Abstract The mechanisms underlying food anticipatory activity are still poorly understood. Here we explored the role of oxytocin (OT) and the protein c-Fos in the supraoptic nucleus (SON), medial (PVNm) and posterior (PVNp) regions of the paraventricular hypothalamic nucleus. Adult rats were assigned to one of four groups: scheduled restricted feeding (RF), ad libitum (AL), fasting after restricted feeding (RF-F), to explore the possible persistence of oscillations, or ad libitum fasted (AL-F). In the SON and in the PVNm, OT cells were c-Fos positive after food intake; in contrast, OT cells in the PVNp showed c-Fos activation in anticipation to food access, which persisted in RF-F subjects. We conclude that OT and non-OT cells of the SON and PVNm may play a role as recipients of the entraining signal provided by food intake, whereas those of the PVNp which contain motor preautonomic cells that project to peripheral organs, may be involved in the hormonal and metabolic anticipatory changes in preparation for food presentation and thus, may be part of a link between central and peripheral oscillators. In addition, due to their persistent activation they may participate in the neuronal network for the clock mechanism that leads to food entrainment.Mario CabaEnrique MezaCarolina EscobarAngeles JiménezMario Daniel Caba-FloresMaría Luisa Moreno-CortésAngel I. MeloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Caba Enrique Meza Carolina Escobar Angeles Jiménez Mario Daniel Caba-Flores María Luisa Moreno-Cortés Angel I. Melo Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
description	Abstract The mechanisms underlying food anticipatory activity are still poorly understood. Here we explored the role of oxytocin (OT) and the protein c-Fos in the supraoptic nucleus (SON), medial (PVNm) and posterior (PVNp) regions of the paraventricular hypothalamic nucleus. Adult rats were assigned to one of four groups: scheduled restricted feeding (RF), ad libitum (AL), fasting after restricted feeding (RF-F), to explore the possible persistence of oscillations, or ad libitum fasted (AL-F). In the SON and in the PVNm, OT cells were c-Fos positive after food intake; in contrast, OT cells in the PVNp showed c-Fos activation in anticipation to food access, which persisted in RF-F subjects. We conclude that OT and non-OT cells of the SON and PVNm may play a role as recipients of the entraining signal provided by food intake, whereas those of the PVNp which contain motor preautonomic cells that project to peripheral organs, may be involved in the hormonal and metabolic anticipatory changes in preparation for food presentation and thus, may be part of a link between central and peripheral oscillators. In addition, due to their persistent activation they may participate in the neuronal network for the clock mechanism that leads to food entrainment.
format	article
author	Mario Caba Enrique Meza Carolina Escobar Angeles Jiménez Mario Daniel Caba-Flores María Luisa Moreno-Cortés Angel I. Melo
author_facet	Mario Caba Enrique Meza Carolina Escobar Angeles Jiménez Mario Daniel Caba-Flores María Luisa Moreno-Cortés Angel I. Melo
author_sort	Mario Caba
title	Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
title_short	Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
title_full	Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
title_fullStr	Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
title_full_unstemmed	Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
title_sort	oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b231caabf3d4f81ad753dc5b0f96c0b
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Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock

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