Effects of the number of drugs used on the prevalence of adverse drug reactions in children
Abstract In pediatric individuals, polypharmacy would increase the prevalence of adverse drug reactions (ADRs). However, there is no report on the ADR increase adjusted for the influence of concomitant disease types. We conducted a retrospective study in pediatric patients to determine whether polyp...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8b2397bd1ef84b7689f5cab07c59e290 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8b2397bd1ef84b7689f5cab07c59e290 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8b2397bd1ef84b7689f5cab07c59e2902021-12-02T12:33:54ZEffects of the number of drugs used on the prevalence of adverse drug reactions in children10.1038/s41598-020-78358-32045-2322https://doaj.org/article/8b2397bd1ef84b7689f5cab07c59e2902020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78358-3https://doaj.org/toc/2045-2322Abstract In pediatric individuals, polypharmacy would increase the prevalence of adverse drug reactions (ADRs). However, there is no report on the ADR increase adjusted for the influence of concomitant disease types. We conducted a retrospective study in pediatric patients to determine whether polypharmacy is a risk factor for ADR development, after the adjustment. Patients aged 1–14 years on medication who visited Gifu Municipal Hospital (Gifu, Japan) were included. We evaluated patient characteristics, ADR causality, ADR classification and severity, and ADR-causing drugs. We examined the association between ADR prevalence and number of drugs used. We performed multiple logistic regression analyses to investigate risk factors for ADR development. Of 1330 patients, 3.5% sought medical attention for ADRs. ADR causality was most often assessed as “possible,” with gastrointestinal ADRs being the most common. Grade 1 ADRs were the most and antibiotics were the most common suspected ADR-inducing drug. The multiple logistic regression analysis showed that ≥ 2 or ≥ 4 drug use, neoplasms, mental and behavioral disorders, and circulatory system diseases significantly increased ADR prevalence. Polypharmacy increased the prevalence of ADR resulting in hospital visits in children, after adjusting for the influence of disease types. Therefore, proactive polypharmacy control measures are necessary for children.Mayuko SugiokaTomoya TachiTakashi MizuiAisa KoyamaAzusa MurayamaHayato KatsunoTakuya MatsuyamaSatoshi AoyamaTomohiro OsawaYoshihiro NoguchiMasahiro YasudaChitoshi GotoHitomi TeramachiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Mayuko Sugioka Tomoya Tachi Takashi Mizui Aisa Koyama Azusa Murayama Hayato Katsuno Takuya Matsuyama Satoshi Aoyama Tomohiro Osawa Yoshihiro Noguchi Masahiro Yasuda Chitoshi Goto Hitomi Teramachi Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| description |
Abstract In pediatric individuals, polypharmacy would increase the prevalence of adverse drug reactions (ADRs). However, there is no report on the ADR increase adjusted for the influence of concomitant disease types. We conducted a retrospective study in pediatric patients to determine whether polypharmacy is a risk factor for ADR development, after the adjustment. Patients aged 1–14 years on medication who visited Gifu Municipal Hospital (Gifu, Japan) were included. We evaluated patient characteristics, ADR causality, ADR classification and severity, and ADR-causing drugs. We examined the association between ADR prevalence and number of drugs used. We performed multiple logistic regression analyses to investigate risk factors for ADR development. Of 1330 patients, 3.5% sought medical attention for ADRs. ADR causality was most often assessed as “possible,” with gastrointestinal ADRs being the most common. Grade 1 ADRs were the most and antibiotics were the most common suspected ADR-inducing drug. The multiple logistic regression analysis showed that ≥ 2 or ≥ 4 drug use, neoplasms, mental and behavioral disorders, and circulatory system diseases significantly increased ADR prevalence. Polypharmacy increased the prevalence of ADR resulting in hospital visits in children, after adjusting for the influence of disease types. Therefore, proactive polypharmacy control measures are necessary for children. |
| format |
article |
| author |
Mayuko Sugioka Tomoya Tachi Takashi Mizui Aisa Koyama Azusa Murayama Hayato Katsuno Takuya Matsuyama Satoshi Aoyama Tomohiro Osawa Yoshihiro Noguchi Masahiro Yasuda Chitoshi Goto Hitomi Teramachi |
| author_facet |
Mayuko Sugioka Tomoya Tachi Takashi Mizui Aisa Koyama Azusa Murayama Hayato Katsuno Takuya Matsuyama Satoshi Aoyama Tomohiro Osawa Yoshihiro Noguchi Masahiro Yasuda Chitoshi Goto Hitomi Teramachi |
| author_sort |
Mayuko Sugioka |
| title |
Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| title_short |
Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| title_full |
Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| title_fullStr |
Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| title_full_unstemmed |
Effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| title_sort |
effects of the number of drugs used on the prevalence of adverse drug reactions in children |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8b2397bd1ef84b7689f5cab07c59e290 |
| work_keys_str_mv |
AT mayukosugioka effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT tomoyatachi effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT takashimizui effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT aisakoyama effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT azusamurayama effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT hayatokatsuno effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT takuyamatsuyama effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT satoshiaoyama effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT tomohiroosawa effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT yoshihironoguchi effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT masahiroyasuda effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT chitoshigoto effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren AT hitomiteramachi effectsofthenumberofdrugsusedontheprevalenceofadversedrugreactionsinchildren |
| _version_ |
1718393870533787648 |