Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and bli...

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Autores principales:	Travis K. Warren, Christopher D. Kane, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Jesse Steffens, Laura Gomba, Jessica M. Weidner, Sarah Norris, Xiankun Zeng, Roy Bannister, Tomas Cihlar, Sina Bavari, Danielle P. Porter, Patrick L. Iversen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c
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spelling	oai:doaj.org-article:8b24a8ac056941f5a1d728fbbaf1db9c2021-12-02T19:16:54ZRemdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus10.1038/s41598-021-98971-02045-2322https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98971-0https://doaj.org/toc/2045-2322Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease.Travis K. WarrenChristopher D. KaneJay WellsKelly S. StuthmanSean A. Van TongerenNicole L. GarzaGinger DonnellyJesse SteffensLaura GombaJessica M. WeidnerSarah NorrisXiankun ZengRoy BannisterTomas CihlarSina BavariDanielle P. PorterPatrick L. IversenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Travis K. Warren Christopher D. Kane Jay Wells Kelly S. Stuthman Sean A. Van Tongeren Nicole L. Garza Ginger Donnelly Jesse Steffens Laura Gomba Jessica M. Weidner Sarah Norris Xiankun Zeng Roy Bannister Tomas Cihlar Sina Bavari Danielle P. Porter Patrick L. Iversen Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
description	Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease.
format	article
author	Travis K. Warren Christopher D. Kane Jay Wells Kelly S. Stuthman Sean A. Van Tongeren Nicole L. Garza Ginger Donnelly Jesse Steffens Laura Gomba Jessica M. Weidner Sarah Norris Xiankun Zeng Roy Bannister Tomas Cihlar Sina Bavari Danielle P. Porter Patrick L. Iversen
author_facet	Travis K. Warren Christopher D. Kane Jay Wells Kelly S. Stuthman Sean A. Van Tongeren Nicole L. Garza Ginger Donnelly Jesse Steffens Laura Gomba Jessica M. Weidner Sarah Norris Xiankun Zeng Roy Bannister Tomas Cihlar Sina Bavari Danielle P. Porter Patrick L. Iversen
author_sort	Travis K. Warren
title	Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_short	Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_full	Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_fullStr	Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_full_unstemmed	Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_sort	remdesivir is efficacious in rhesus monkeys exposed to aerosolized ebola virus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c
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Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

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