POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES

It was revealed, that, in blood samples of the patients with autoimmune thyroid diseases, serum antibodies against cell-free fraction of Bifidobacterium bifidum 791 and Lactobacillus plantarum B-01 were detected, respectively, in 71 and 63% of cases, that being two-fold higher than appropriate frequ...

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Autores principales:	E. P. Kiseleva, O. V. Tsyganova, K. I. Mikhailopulo, O. V. Sviridov, Y. E. Demidchic, A. V. Izhik, Y. A. Knirel, G. I. Novik
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bifidobacterium lactobacillus thyroglobulins antibodies molecular mimicry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8b25441bd0194e57af2de5269ba25700
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spelling	oai:doaj.org-article:8b25441bd0194e57af2de5269ba257002021-11-18T08:03:37ZPOSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES1563-06252313-741X10.15789/1563-0625-2010-1-2-71-80https://doaj.org/article/8b25441bd0194e57af2de5269ba257002014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/45https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIt was revealed, that, in blood samples of the patients with autoimmune thyroid diseases, serum antibodies against cell-free fraction of Bifidobacterium bifidum 791 and Lactobacillus plantarum B-01 were detected, respectively, in 71 and 63% of cases, that being two-fold higher than appropriate frequencies in healthy blood donors. An evidence was obtained that presence of some components specifically reacting with autoantibodies against thyroid peroxidase and thyroglobulin on the surface of the microorganisms cells and competing for binding of these immunoglobulins with thyroid antigens. One may also suggest a presence of bacterial components, interacting with thyroid peroxidase. The data obtained let us suggest that probiotic microorganisms of Bifidobacterium and Lactobacillus genus could take part in pathogenesis of autoimmune thyroid diseases, by means of molecular mimicry mechanisms.E. P. KiselevaO. V. TsyganovaK. I. MikhailopuloO. V. SviridovY. E. DemidchicA. V. IzhikY. A. KnirelG. I. NovikSPb RAACIarticlebifidobacteriumlactobacillusthyroglobulinsantibodiesmolecular mimicryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 71-80 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bifidobacterium lactobacillus thyroglobulins antibodies molecular mimicry Immunologic diseases. Allergy RC581-607
spellingShingle	bifidobacterium lactobacillus thyroglobulins antibodies molecular mimicry Immunologic diseases. Allergy RC581-607 E. P. Kiseleva O. V. Tsyganova K. I. Mikhailopulo O. V. Sviridov Y. E. Demidchic A. V. Izhik Y. A. Knirel G. I. Novik POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
description	It was revealed, that, in blood samples of the patients with autoimmune thyroid diseases, serum antibodies against cell-free fraction of Bifidobacterium bifidum 791 and Lactobacillus plantarum B-01 were detected, respectively, in 71 and 63% of cases, that being two-fold higher than appropriate frequencies in healthy blood donors. An evidence was obtained that presence of some components specifically reacting with autoantibodies against thyroid peroxidase and thyroglobulin on the surface of the microorganisms cells and competing for binding of these immunoglobulins with thyroid antigens. One may also suggest a presence of bacterial components, interacting with thyroid peroxidase. The data obtained let us suggest that probiotic microorganisms of Bifidobacterium and Lactobacillus genus could take part in pathogenesis of autoimmune thyroid diseases, by means of molecular mimicry mechanisms.
format	article
author	E. P. Kiseleva O. V. Tsyganova K. I. Mikhailopulo O. V. Sviridov Y. E. Demidchic A. V. Izhik Y. A. Knirel G. I. Novik
author_facet	E. P. Kiseleva O. V. Tsyganova K. I. Mikhailopulo O. V. Sviridov Y. E. Demidchic A. V. Izhik Y. A. Knirel G. I. Novik
author_sort	E. P. Kiseleva
title	POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
title_short	POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
title_full	POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
title_fullStr	POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
title_full_unstemmed	POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
title_sort	possible role of probiotic microorganisms of bifidobacterium and lactobacillus genus in pathogenesis of autoimmune thyroid diseases
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8b25441bd0194e57af2de5269ba25700
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POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES

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