Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies

Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in brin...

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Autores principales:	Suelen Lucio Boschen, James Trevathan, Seth A. Hara, Anders Asp, J. Luis Lujan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clinical neurochemistry deep brain stimulation fast scan cyclic voltammetry intraoperative neurochemical signaling neurophysiology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8b25810dbce24dfcb0e2123d0a2ef390
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spelling	oai:doaj.org-article:8b25810dbce24dfcb0e2123d0a2ef3902021-11-12T06:59:05ZDefining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies1662-453X10.3389/fnins.2021.728092https://doaj.org/article/8b25810dbce24dfcb0e2123d0a2ef3902021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.728092/fullhttps://doaj.org/toc/1662-453XFast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in bringing FSCV into clinical use. However, there remain technical challenges that limit clinical implementation of FSCV by creating barriers to appropriate scientific rigor and patient safety. In order to progress with clinical FSCV, these limitations must be first addressed through (1) appropriate pre-clinical studies to ensure accurate measurement of neurotransmitters and (2) the application of a risk management framework to assess patient safety. The intent of this work is to bring awareness of the current issues associated with FSCV to the scientific, engineering, and clinical communities and encourage them to seek solutions or alternatives that ensure data accuracy, rigor and reproducibility, and patient safety.Suelen Lucio BoschenJames TrevathanSeth A. HaraAnders AspAnders AspJ. Luis LujanJ. Luis LujanFrontiers Media S.A.articleclinical neurochemistrydeep brain stimulationfast scan cyclic voltammetryintraoperativeneurochemical signalingneurophysiologyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical neurochemistry deep brain stimulation fast scan cyclic voltammetry intraoperative neurochemical signaling neurophysiology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	clinical neurochemistry deep brain stimulation fast scan cyclic voltammetry intraoperative neurochemical signaling neurophysiology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
description	Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in bringing FSCV into clinical use. However, there remain technical challenges that limit clinical implementation of FSCV by creating barriers to appropriate scientific rigor and patient safety. In order to progress with clinical FSCV, these limitations must be first addressed through (1) appropriate pre-clinical studies to ensure accurate measurement of neurotransmitters and (2) the application of a risk management framework to assess patient safety. The intent of this work is to bring awareness of the current issues associated with FSCV to the scientific, engineering, and clinical communities and encourage them to seek solutions or alternatives that ensure data accuracy, rigor and reproducibility, and patient safety.
format	article
author	Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan
author_facet	Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan
author_sort	Suelen Lucio Boschen
title	Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
title_short	Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
title_full	Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
title_fullStr	Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
title_full_unstemmed	Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
title_sort	defining a path toward the use of fast-scan cyclic voltammetry in human studies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8b25810dbce24dfcb0e2123d0a2ef390
work_keys_str_mv	AT suelenlucioboschen definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT jamestrevathan definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT sethahara definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT andersasp definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT andersasp definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT jluislujan definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies AT jluislujan definingapathtowardtheuseoffastscancyclicvoltammetryinhumanstudies
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Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies

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