Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy

Abstract We investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 2...

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Autores principales:	Yoshitaka Ueno, Takeshi Iwase, Kensuke Goto, Ryo Tomita, Eimei Ra, Kentaro Yamamoto, Hiroko Terasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b27b36676c94efdb9e918c64b976f80
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spelling	oai:doaj.org-article:8b27b36676c94efdb9e918c64b976f802021-12-02T13:19:23ZAssociation of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy10.1038/s41598-021-84067-22045-2322https://doaj.org/article/8b27b36676c94efdb9e918c64b976f802021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84067-2https://doaj.org/toc/2045-2322Abstract We investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all P < 0.001). However, the external diameter of the retinal vessels was not significantly different among the groups. The mean blur rate (MBR)-vessel determined by laser speckle flowgraphy was significantly lower in the PDR group than in the other groups (P < 0.001). The WLR was correlated with MBR-vessel (r = − 0.337, P < 0.001), duration of disease (r = 0.191, P = 0.042), stage of DM (r = 0.643, P < 0.001), systolic blood pressure (r = 0.166, P < 0.037), and presence of systemic hypertension (r = 0.443, P < 0.001). Multiple regression analysis demonstrated that MBR-vessel (β = − 0.389, P < 0.001), presence of systemic hypertension (β = 0.334, P = 0.001), and LDL (β = 0.199, P = 0.045) were independent factors significantly associated with the WLR. The increased retinal vessel wall thickness led to a narrowing of lumen diameter and a decrease in the blood flow in the PDR group.Yoshitaka UenoTakeshi IwaseKensuke GotoRyo TomitaEimei RaKentaro YamamotoHiroko TerasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshitaka Ueno Takeshi Iwase Kensuke Goto Ryo Tomita Eimei Ra Kentaro Yamamoto Hiroko Terasaki Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
description	Abstract We investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all P < 0.001). However, the external diameter of the retinal vessels was not significantly different among the groups. The mean blur rate (MBR)-vessel determined by laser speckle flowgraphy was significantly lower in the PDR group than in the other groups (P < 0.001). The WLR was correlated with MBR-vessel (r = − 0.337, P < 0.001), duration of disease (r = 0.191, P = 0.042), stage of DM (r = 0.643, P < 0.001), systolic blood pressure (r = 0.166, P < 0.037), and presence of systemic hypertension (r = 0.443, P < 0.001). Multiple regression analysis demonstrated that MBR-vessel (β = − 0.389, P < 0.001), presence of systemic hypertension (β = 0.334, P = 0.001), and LDL (β = 0.199, P = 0.045) were independent factors significantly associated with the WLR. The increased retinal vessel wall thickness led to a narrowing of lumen diameter and a decrease in the blood flow in the PDR group.
format	article
author	Yoshitaka Ueno Takeshi Iwase Kensuke Goto Ryo Tomita Eimei Ra Kentaro Yamamoto Hiroko Terasaki
author_facet	Yoshitaka Ueno Takeshi Iwase Kensuke Goto Ryo Tomita Eimei Ra Kentaro Yamamoto Hiroko Terasaki
author_sort	Yoshitaka Ueno
title	Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
title_short	Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
title_full	Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
title_fullStr	Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
title_full_unstemmed	Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
title_sort	association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b27b36676c94efdb9e918c64b976f80
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Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy

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