Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Abstract Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (β2AR) agonist formoterol induces mitochondrial biogenesis (MB), but other β2AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway...

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Autores principales: Robert B. Cameron, Yuri K. Peterson, Craig C. Beeson, Rick G. Schnellmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/8b2addff23fe41f2a5df5b8a3510a7ca
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