Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via extracellular vesicles which could deliver th...
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Nature Portfolio
2019
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oai:doaj.org-article:8b2d6ac14e79424d88fcb0a687a8a9322021-12-02T16:57:52ZLinkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells10.1038/s41467-019-12275-62041-1723https://doaj.org/article/8b2d6ac14e79424d88fcb0a687a8a9322019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12275-6https://doaj.org/toc/2041-1723Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via extracellular vesicles which could deliver the functional mRNA to other cells.Marco MaugeriMuhammad NawazAlexandros PapadimitriouAnnelie AngerforsAlessandro CamponeschiManli NaMikko HölttäPia SkantzeSvante JohanssonMartina SundqvistJohnny LindquistTomas KjellmanInga-Lill MårtenssonTao JinPer SunnerhagenSofia ÖstmanLennart LindforsHadi ValadiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marco Maugeri Muhammad Nawaz Alexandros Papadimitriou Annelie Angerfors Alessandro Camponeschi Manli Na Mikko Hölttä Pia Skantze Svante Johansson Martina Sundqvist Johnny Lindquist Tomas Kjellman Inga-Lill Mårtensson Tao Jin Per Sunnerhagen Sofia Östman Lennart Lindfors Hadi Valadi Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| description |
Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via extracellular vesicles which could deliver the functional mRNA to other cells. |
| format |
article |
| author |
Marco Maugeri Muhammad Nawaz Alexandros Papadimitriou Annelie Angerfors Alessandro Camponeschi Manli Na Mikko Hölttä Pia Skantze Svante Johansson Martina Sundqvist Johnny Lindquist Tomas Kjellman Inga-Lill Mårtensson Tao Jin Per Sunnerhagen Sofia Östman Lennart Lindfors Hadi Valadi |
| author_facet |
Marco Maugeri Muhammad Nawaz Alexandros Papadimitriou Annelie Angerfors Alessandro Camponeschi Manli Na Mikko Hölttä Pia Skantze Svante Johansson Martina Sundqvist Johnny Lindquist Tomas Kjellman Inga-Lill Mårtensson Tao Jin Per Sunnerhagen Sofia Östman Lennart Lindfors Hadi Valadi |
| author_sort |
Marco Maugeri |
| title |
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| title_short |
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| title_full |
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| title_fullStr |
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| title_full_unstemmed |
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells |
| title_sort |
linkage between endosomal escape of lnp-mrna and loading into evs for transport to other cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/8b2d6ac14e79424d88fcb0a687a8a932 |
| work_keys_str_mv |
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| _version_ |
1718382457552633856 |