Gating mechanism of elongating β-ketoacyl-ACP synthases

The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the catalytic mechanism underlying C-C bond formi...

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Autores principales:	Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
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spelling	oai:doaj.org-article:8b2f324577e8467b8bb69a969b0ffd832021-12-02T16:50:02ZGating mechanism of elongating β-ketoacyl-ACP synthases10.1038/s41467-020-15455-x2041-1723https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd832020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15455-xhttps://doaj.org/toc/2041-1723The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the catalytic mechanism underlying C-C bond forming reactions.Jeffrey T. MindreboAshay PatelWoojoo E. KimTony D. DavisAochiu ChenThomas G. BartholowJames J. La ClairJ. Andrew McCammonJoseph P. NoelMichael D. BurkartNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey T. Mindrebo Ashay Patel Woojoo E. Kim Tony D. Davis Aochiu Chen Thomas G. Bartholow James J. La Clair J. Andrew McCammon Joseph P. Noel Michael D. Burkart Gating mechanism of elongating β-ketoacyl-ACP synthases
description	The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the catalytic mechanism underlying C-C bond forming reactions.
format	article
author	Jeffrey T. Mindrebo Ashay Patel Woojoo E. Kim Tony D. Davis Aochiu Chen Thomas G. Bartholow James J. La Clair J. Andrew McCammon Joseph P. Noel Michael D. Burkart
author_facet	Jeffrey T. Mindrebo Ashay Patel Woojoo E. Kim Tony D. Davis Aochiu Chen Thomas G. Bartholow James J. La Clair J. Andrew McCammon Joseph P. Noel Michael D. Burkart
author_sort	Jeffrey T. Mindrebo
title	Gating mechanism of elongating β-ketoacyl-ACP synthases
title_short	Gating mechanism of elongating β-ketoacyl-ACP synthases
title_full	Gating mechanism of elongating β-ketoacyl-ACP synthases
title_fullStr	Gating mechanism of elongating β-ketoacyl-ACP synthases
title_full_unstemmed	Gating mechanism of elongating β-ketoacyl-ACP synthases
title_sort	gating mechanism of elongating β-ketoacyl-acp synthases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
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Gating mechanism of elongating β-ketoacyl-ACP synthases

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