Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study

Abstract Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that...

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Autores principales:	Dorien M. Kimenai, Remy J. H. Martens, Jeroen P. Kooman, Coen D. A. Stehouwer, Frans E. S. Tan, Nicolaas C. Schaper, Pieter C. Dagnelie, Miranda T. Schram, Carla J. H. van der Kallen, Simone J. S. Sep, Jeroen D. E. van Suijlen, Abraham A. Kroon, Otto Bekers, Marja P. van Dieijen-Visser, Ronald M. A. Henry, Steven J. R. Meex
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b30408b346c4d62ab48664acb2cf641
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spelling	oai:doaj.org-article:8b30408b346c4d62ab48664acb2cf6412021-12-02T12:32:13ZTroponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study10.1038/s41598-017-06978-32045-2322https://doaj.org/article/8b30408b346c4d62ab48664acb2cf6412017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06978-3https://doaj.org/toc/2045-2322Abstract Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that may underlie the associations between troponin levels and mortality in the general population. In the population-based Maastricht Study, we assessed the correlation and concordance between hs-cTnI and hs-cTnT. Multiple regression analyses were conducted to assess the association of hs-cTnI and hs-cTnT with electrocardiographic (ECG) changes indicative of cardiac abnormalities. In 3016 eligible individuals(mean age,60 ± 8years;50.6%,men) we found a modest correlation between hs-cTnI and hs-cTnT(r = 0.585). After multiple adjustment, the association with ECG changes indicative of cardiac abnormalities was similar for both hs-cTn assays(OR,hs-cTnI:1.72,95%CI:1.40-2.10;OR,hs-cTnT:1.60,95%CI:1.22–2.11). The concordance of dichotomized hs-cTnI and hs-cTnT was κ = 0.397(≥sex-specific 75th percentile). Isolated high levels of hs-cTnI were associated with ECG changes indicative of cardiac abnormalities(OR:1.93,95%CI:1.01–3.68), whereas isolated high levels of hs-cTnT were not(OR:1.07,95%CI:0.49–2.31). In conclusion, there is a moderate correlation and limited concordance between hs-cTnI and hs-cTnT under non-acute conditions. These data suggest that associations of hs-cTnI and hs-cTnT with cardiac injury detected by ECG are driven by different mechanisms. This information may benefit future development of CVD risk stratification algorithms.Dorien M. KimenaiRemy J. H. MartensJeroen P. KoomanCoen D. A. StehouwerFrans E. S. TanNicolaas C. SchaperPieter C. DagnelieMiranda T. SchramCarla J. H. van der KallenSimone J. S. SepJeroen D. E. van SuijlenAbraham A. KroonOtto BekersMarja P. van Dieijen-VisserRonald M. A. HenrySteven J. R. MeexNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dorien M. Kimenai Remy J. H. Martens Jeroen P. Kooman Coen D. A. Stehouwer Frans E. S. Tan Nicolaas C. Schaper Pieter C. Dagnelie Miranda T. Schram Carla J. H. van der Kallen Simone J. S. Sep Jeroen D. E. van Suijlen Abraham A. Kroon Otto Bekers Marja P. van Dieijen-Visser Ronald M. A. Henry Steven J. R. Meex Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
description	Abstract Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that may underlie the associations between troponin levels and mortality in the general population. In the population-based Maastricht Study, we assessed the correlation and concordance between hs-cTnI and hs-cTnT. Multiple regression analyses were conducted to assess the association of hs-cTnI and hs-cTnT with electrocardiographic (ECG) changes indicative of cardiac abnormalities. In 3016 eligible individuals(mean age,60 ± 8years;50.6%,men) we found a modest correlation between hs-cTnI and hs-cTnT(r = 0.585). After multiple adjustment, the association with ECG changes indicative of cardiac abnormalities was similar for both hs-cTn assays(OR,hs-cTnI:1.72,95%CI:1.40-2.10;OR,hs-cTnT:1.60,95%CI:1.22–2.11). The concordance of dichotomized hs-cTnI and hs-cTnT was κ = 0.397(≥sex-specific 75th percentile). Isolated high levels of hs-cTnI were associated with ECG changes indicative of cardiac abnormalities(OR:1.93,95%CI:1.01–3.68), whereas isolated high levels of hs-cTnT were not(OR:1.07,95%CI:0.49–2.31). In conclusion, there is a moderate correlation and limited concordance between hs-cTnI and hs-cTnT under non-acute conditions. These data suggest that associations of hs-cTnI and hs-cTnT with cardiac injury detected by ECG are driven by different mechanisms. This information may benefit future development of CVD risk stratification algorithms.
format	article
author	Dorien M. Kimenai Remy J. H. Martens Jeroen P. Kooman Coen D. A. Stehouwer Frans E. S. Tan Nicolaas C. Schaper Pieter C. Dagnelie Miranda T. Schram Carla J. H. van der Kallen Simone J. S. Sep Jeroen D. E. van Suijlen Abraham A. Kroon Otto Bekers Marja P. van Dieijen-Visser Ronald M. A. Henry Steven J. R. Meex
author_facet	Dorien M. Kimenai Remy J. H. Martens Jeroen P. Kooman Coen D. A. Stehouwer Frans E. S. Tan Nicolaas C. Schaper Pieter C. Dagnelie Miranda T. Schram Carla J. H. van der Kallen Simone J. S. Sep Jeroen D. E. van Suijlen Abraham A. Kroon Otto Bekers Marja P. van Dieijen-Visser Ronald M. A. Henry Steven J. R. Meex
author_sort	Dorien M. Kimenai
title	Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
title_short	Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
title_full	Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
title_fullStr	Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
title_full_unstemmed	Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study
title_sort	troponin i and t in relation to cardiac injury detected with electrocardiography in a population-based cohort - the maastricht study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8b30408b346c4d62ab48664acb2cf641
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Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study

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