Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action

ABSTRACT We describe a novel symbiotic association between a kinetoplastid protist, Novymonas esmeraldas gen. nov., sp. nov., and an intracytoplasmic bacterium, “Candidatus Pandoraea novymonadis” sp. nov., discovered as a result of a broad-scale survey of insect trypanosomatid biodiversity in Ecuado...

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Autores principales:	Alexei Y. Kostygov, Eva Dobáková, Anastasiia Grybchuk-Ieremenko, Dalibor Váhala, Dmitri A. Maslov, Jan Votýpka, Julius Lukeš, Vyacheslav Yurchenko
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8b3048992e4b40faad0847c13e9bc094
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spelling	oai:doaj.org-article:8b3048992e4b40faad0847c13e9bc0942021-11-15T15:41:41ZNovel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action10.1128/mBio.01985-152150-7511https://doaj.org/article/8b3048992e4b40faad0847c13e9bc0942016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01985-15https://doaj.org/toc/2150-7511ABSTRACT We describe a novel symbiotic association between a kinetoplastid protist, Novymonas esmeraldas gen. nov., sp. nov., and an intracytoplasmic bacterium, “Candidatus Pandoraea novymonadis” sp. nov., discovered as a result of a broad-scale survey of insect trypanosomatid biodiversity in Ecuador. We characterize this association by describing the morphology of both organisms, as well as their interactions, and by establishing their phylogenetic affinities. Importantly, neither partner is closely related to other known organisms previously implicated in eukaryote-bacterial symbiosis. This symbiotic association seems to be relatively recent, as the host does not exert a stringent control over the number of bacteria harbored in its cytoplasm. We argue that this unique relationship may represent a suitable model for studying the initial stages of establishment of endosymbiosis between a single-cellular eukaryote and a prokaryote. Based on phylogenetic analyses, Novymonas could be considered a proxy for the insect-only ancestor of the dixenous genus Leishmania and shed light on the origin of the two-host life cycle within the subfamily Leishmaniinae. IMPORTANCE The parasitic trypanosomatid protist Novymonas esmeraldas gen. nov., sp. nov. entered into endosymbiosis with the bacterium “Ca. Pandoraea novymonadis” sp. nov. This novel and rather unstable interaction shows several signs of relatively recent establishment, qualifying it as a potentially unique transient stage in the increasingly complex range of eukaryotic-prokaryotic relationships.Alexei Y. KostygovEva DobákováAnastasiia Grybchuk-IeremenkoDalibor VáhalaDmitri A. MaslovJan VotýpkaJulius LukešVyacheslav YurchenkoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Alexei Y. Kostygov Eva Dobáková Anastasiia Grybchuk-Ieremenko Dalibor Váhala Dmitri A. Maslov Jan Votýpka Julius Lukeš Vyacheslav Yurchenko Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
description	ABSTRACT We describe a novel symbiotic association between a kinetoplastid protist, Novymonas esmeraldas gen. nov., sp. nov., and an intracytoplasmic bacterium, “Candidatus Pandoraea novymonadis” sp. nov., discovered as a result of a broad-scale survey of insect trypanosomatid biodiversity in Ecuador. We characterize this association by describing the morphology of both organisms, as well as their interactions, and by establishing their phylogenetic affinities. Importantly, neither partner is closely related to other known organisms previously implicated in eukaryote-bacterial symbiosis. This symbiotic association seems to be relatively recent, as the host does not exert a stringent control over the number of bacteria harbored in its cytoplasm. We argue that this unique relationship may represent a suitable model for studying the initial stages of establishment of endosymbiosis between a single-cellular eukaryote and a prokaryote. Based on phylogenetic analyses, Novymonas could be considered a proxy for the insect-only ancestor of the dixenous genus Leishmania and shed light on the origin of the two-host life cycle within the subfamily Leishmaniinae. IMPORTANCE The parasitic trypanosomatid protist Novymonas esmeraldas gen. nov., sp. nov. entered into endosymbiosis with the bacterium “Ca. Pandoraea novymonadis” sp. nov. This novel and rather unstable interaction shows several signs of relatively recent establishment, qualifying it as a potentially unique transient stage in the increasingly complex range of eukaryotic-prokaryotic relationships.
format	article
author	Alexei Y. Kostygov Eva Dobáková Anastasiia Grybchuk-Ieremenko Dalibor Váhala Dmitri A. Maslov Jan Votýpka Julius Lukeš Vyacheslav Yurchenko
author_facet	Alexei Y. Kostygov Eva Dobáková Anastasiia Grybchuk-Ieremenko Dalibor Váhala Dmitri A. Maslov Jan Votýpka Julius Lukeš Vyacheslav Yurchenko
author_sort	Alexei Y. Kostygov
title	Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
title_short	Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
title_full	Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
title_fullStr	Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
title_full_unstemmed	Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action
title_sort	novel trypanosomatid-bacterium association: evolution of endosymbiosis in action
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/8b3048992e4b40faad0847c13e9bc094
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Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action

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