CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE

On the basis of clinical observations in eighty-eight persons with chronic obstructive lung disease (COPD) at mild, moderate and severe clinical stages, and twenty-two persons with chronic bronchitis in recurrence phase, we have revealed some features of immune disturbances in various clinical forms...

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Autores principales:	T. O. Kostrova, G. V. Lisachenko, A. V. Shabaldin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune state chronic obstructive lung disease immune deficiency t helpers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8b40ffa4f910495bbda0082599f6d738
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spelling	oai:doaj.org-article:8b40ffa4f910495bbda0082599f6d7382021-11-18T08:03:37ZCLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE1563-06252313-741X10.15789/1563-0625-2010-3-207-212https://doaj.org/article/8b40ffa4f910495bbda0082599f6d7382014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/91https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOn the basis of clinical observations in eighty-eight persons with chronic obstructive lung disease (COPD) at mild, moderate and severe clinical stages, and twenty-two persons with chronic bronchitis in recurrence phase, we have revealed some features of immune disturbances in various clinical forms of ventilation disorders. A direct dependence between severity of main disorder and the degree of cellular immune deficiency was shown, manifesting as low expression of early and late activation markers (resp., СD25 and HLA-DR). We have revealed a coupling between severity of clinical manifestations, degree of ventilation problems, and disturbances of immune response in COPD patients. This immune response depends on the level of T-helpers, expression of early and late activation markers.T. O. KostrovaG. V. LisachenkoA. V. ShabaldinSPb RAACIarticleimmune statechronic obstructive lung diseaseimmune deficiencyt helpersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 3, Pp 207-212 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune state chronic obstructive lung disease immune deficiency t helpers Immunologic diseases. Allergy RC581-607
spellingShingle	immune state chronic obstructive lung disease immune deficiency t helpers Immunologic diseases. Allergy RC581-607 T. O. Kostrova G. V. Lisachenko A. V. Shabaldin CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
description	On the basis of clinical observations in eighty-eight persons with chronic obstructive lung disease (COPD) at mild, moderate and severe clinical stages, and twenty-two persons with chronic bronchitis in recurrence phase, we have revealed some features of immune disturbances in various clinical forms of ventilation disorders. A direct dependence between severity of main disorder and the degree of cellular immune deficiency was shown, manifesting as low expression of early and late activation markers (resp., СD25 and HLA-DR). We have revealed a coupling between severity of clinical manifestations, degree of ventilation problems, and disturbances of immune response in COPD patients. This immune response depends on the level of T-helpers, expression of early and late activation markers.
format	article
author	T. O. Kostrova G. V. Lisachenko A. V. Shabaldin
author_facet	T. O. Kostrova G. V. Lisachenko A. V. Shabaldin
author_sort	T. O. Kostrova
title	CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
title_short	CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
title_full	CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
title_fullStr	CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
title_sort	clinical and immunological aspects of chronic obstructive lung disease
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8b40ffa4f910495bbda0082599f6d738
work_keys_str_mv	AT tokostrova clinicalandimmunologicalaspectsofchronicobstructivelungdisease AT gvlisachenko clinicalandimmunologicalaspectsofchronicobstructivelungdisease AT avshabaldin clinicalandimmunologicalaspectsofchronicobstructivelungdisease
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CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE

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