Use of oral iron in managing iron deficiency anemia in children with intestinal failure

Background & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is c...

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Autores principales:	Badr Alsaleem, Nora Albanyan, Ahmad Alamer, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Mohannad M. Alrahili, Amna B. Albasheer, Ahmed A. Alrashed, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Intestinal failure Iron deficiency anemia Oral iron Total parenteral nutrition Children Ferritin Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/8b47cca1d3e54e489bc6f9be91282a92
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spelling	oai:doaj.org-article:8b47cca1d3e54e489bc6f9be91282a922021-11-18T04:43:57ZUse of oral iron in managing iron deficiency anemia in children with intestinal failure1018-364710.1016/j.jksus.2021.101601https://doaj.org/article/8b47cca1d3e54e489bc6f9be91282a922021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721002639https://doaj.org/toc/1018-3647Background & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is common. This study used a quasi-experimental approach to assess the efficacy and safety of oral iron therapy in treating IDA in TPN-dependent children with IF. Materials and Methods: Sixteen pediatric patients with an ongoing history of IF, TPN dependency, and iron deficiency anemia were enrolled and given an oral iron syrup dose of ferric hydroxide polymaltose complex (6 mg/kg/day in 2–3 separate doses of elemental iron) after receiving ethical approval and parental consent. Blood tests were done to measure serum iron, ferritin, complete iron-binding capacity [TIBC], transferrin saturation [TSAT], and hemoglobin (Hb) level at the time of inclusion (T0), 14 (T14), and 30 days after treatment (T30). Results: The mean age was 7.13 (±1.99) and female were 12 (75%). No remarkable change in Hb level was noted in the first and second subsequent follow-ups, notwithstanding, the normal estimation of the serum ferritin level significantly increased during the first follow-up (on fourteenth day) which further enhanced by second follow-up (30th day). The aggregate of the total iron binding capacity (TIBC) declined during the course of oral iron therapy with a reduction in transferrin saturation. Interpretation & Conclusion: The data suggest that oral iron therapy is unsuccessful in the treatment of IDA in children with IF. There is no substantial improvement in hemoglobin level or iron profile aside from serum ferritin. In order to avoid using parenteral iron in IF patients, an additional supportive system is needed to aid in the integration of oral iron therapy.Badr AlsaleemNora AlbanyanAhmad AlamerSyed Mohammed Basheeruddin AsdaqYahya MohzariMohannad M. AlrahiliAmna B. AlbasheerAhmed A. AlrashedAbdulhakeem S. AlamriWalaa F. AlsanieMajid AlhomraniElsevierarticleIntestinal failureIron deficiency anemiaOral ironTotal parenteral nutritionChildrenFerritinScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101601- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intestinal failure Iron deficiency anemia Oral iron Total parenteral nutrition Children Ferritin Science (General) Q1-390
spellingShingle	Intestinal failure Iron deficiency anemia Oral iron Total parenteral nutrition Children Ferritin Science (General) Q1-390 Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani Use of oral iron in managing iron deficiency anemia in children with intestinal failure
description	Background & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is common. This study used a quasi-experimental approach to assess the efficacy and safety of oral iron therapy in treating IDA in TPN-dependent children with IF. Materials and Methods: Sixteen pediatric patients with an ongoing history of IF, TPN dependency, and iron deficiency anemia were enrolled and given an oral iron syrup dose of ferric hydroxide polymaltose complex (6 mg/kg/day in 2–3 separate doses of elemental iron) after receiving ethical approval and parental consent. Blood tests were done to measure serum iron, ferritin, complete iron-binding capacity [TIBC], transferrin saturation [TSAT], and hemoglobin (Hb) level at the time of inclusion (T0), 14 (T14), and 30 days after treatment (T30). Results: The mean age was 7.13 (±1.99) and female were 12 (75%). No remarkable change in Hb level was noted in the first and second subsequent follow-ups, notwithstanding, the normal estimation of the serum ferritin level significantly increased during the first follow-up (on fourteenth day) which further enhanced by second follow-up (30th day). The aggregate of the total iron binding capacity (TIBC) declined during the course of oral iron therapy with a reduction in transferrin saturation. Interpretation & Conclusion: The data suggest that oral iron therapy is unsuccessful in the treatment of IDA in children with IF. There is no substantial improvement in hemoglobin level or iron profile aside from serum ferritin. In order to avoid using parenteral iron in IF patients, an additional supportive system is needed to aid in the integration of oral iron therapy.
format	article
author	Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani
author_facet	Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani
author_sort	Badr Alsaleem
title	Use of oral iron in managing iron deficiency anemia in children with intestinal failure
title_short	Use of oral iron in managing iron deficiency anemia in children with intestinal failure
title_full	Use of oral iron in managing iron deficiency anemia in children with intestinal failure
title_fullStr	Use of oral iron in managing iron deficiency anemia in children with intestinal failure
title_full_unstemmed	Use of oral iron in managing iron deficiency anemia in children with intestinal failure
title_sort	use of oral iron in managing iron deficiency anemia in children with intestinal failure
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8b47cca1d3e54e489bc6f9be91282a92
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Use of oral iron in managing iron deficiency anemia in children with intestinal failure

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