Epidemiological and Immunological Features of Obesity and SARS-CoV-2

Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demog...

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Autores principales:	Eric J. Nilles, Sameed M. Siddiqui, Stephanie Fischinger, Yannic C. Bartsch, Michael de St. Aubin, Guohai Zhou, Matthew J. Gluck, Samuel Berger, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael Loesche, Yiyuan Hu, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline Atyeo, Matthew J. Gorman, Alex Lee Zhu, John Burke, Matthew Slein, Mohammad A. Hasdianda, Guruprasad Jambaulikar, Edward W. Boyer, Pardis C. Sabeti, Dan H. Barouch, Boris Julg, Adam J. Kucharski, Elon R. Musk, Douglas A. Lauffenburger, Galit Alter, Anil S. Menon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 body mass index obesity epidemiology clinical features Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8b482925babd4a6182e66dd7d2a77ac0
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spelling	oai:doaj.org-article:8b482925babd4a6182e66dd7d2a77ac02021-11-25T19:13:37ZEpidemiological and Immunological Features of Obesity and SARS-CoV-210.3390/v131122351999-4915https://doaj.org/article/8b482925babd4a6182e66dd7d2a77ac02021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2235https://doaj.org/toc/1999-4915Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.Eric J. NillesSameed M. SiddiquiStephanie FischingerYannic C. BartschMichael de St. AubinGuohai ZhouMatthew J. GluckSamuel BergerJustin RheeEric PetersenBenjamin MormannMichael LoescheYiyuan HuZhilin ChenJingyou YuMakda GebreCaroline AtyeoMatthew J. GormanAlex Lee ZhuJohn BurkeMatthew SleinMohammad A. HasdiandaGuruprasad JambaulikarEdward W. BoyerPardis C. SabetiDan H. BarouchBoris JulgAdam J. KucharskiElon R. MuskDouglas A. LauffenburgerGalit AlterAnil S. MenonMDPI AGarticleSARS-CoV-2COVID-19body mass indexobesityepidemiologyclinical featuresMicrobiologyQR1-502ENViruses, Vol 13, Iss 2235, p 2235 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 body mass index obesity epidemiology clinical features Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 body mass index obesity epidemiology clinical features Microbiology QR1-502 Eric J. Nilles Sameed M. Siddiqui Stephanie Fischinger Yannic C. Bartsch Michael de St. Aubin Guohai Zhou Matthew J. Gluck Samuel Berger Justin Rhee Eric Petersen Benjamin Mormann Michael Loesche Yiyuan Hu Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu John Burke Matthew Slein Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris Julg Adam J. Kucharski Elon R. Musk Douglas A. Lauffenburger Galit Alter Anil S. Menon Epidemiological and Immunological Features of Obesity and SARS-CoV-2
description	Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.
format	article
author	Eric J. Nilles Sameed M. Siddiqui Stephanie Fischinger Yannic C. Bartsch Michael de St. Aubin Guohai Zhou Matthew J. Gluck Samuel Berger Justin Rhee Eric Petersen Benjamin Mormann Michael Loesche Yiyuan Hu Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu John Burke Matthew Slein Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris Julg Adam J. Kucharski Elon R. Musk Douglas A. Lauffenburger Galit Alter Anil S. Menon
author_facet	Eric J. Nilles Sameed M. Siddiqui Stephanie Fischinger Yannic C. Bartsch Michael de St. Aubin Guohai Zhou Matthew J. Gluck Samuel Berger Justin Rhee Eric Petersen Benjamin Mormann Michael Loesche Yiyuan Hu Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu John Burke Matthew Slein Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris Julg Adam J. Kucharski Elon R. Musk Douglas A. Lauffenburger Galit Alter Anil S. Menon
author_sort	Eric J. Nilles
title	Epidemiological and Immunological Features of Obesity and SARS-CoV-2
title_short	Epidemiological and Immunological Features of Obesity and SARS-CoV-2
title_full	Epidemiological and Immunological Features of Obesity and SARS-CoV-2
title_fullStr	Epidemiological and Immunological Features of Obesity and SARS-CoV-2
title_full_unstemmed	Epidemiological and Immunological Features of Obesity and SARS-CoV-2
title_sort	epidemiological and immunological features of obesity and sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8b482925babd4a6182e66dd7d2a77ac0
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Epidemiological and Immunological Features of Obesity and SARS-CoV-2

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