Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.

The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as thalamic atrophy and white matter lesion load, an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Prejaas Tewarie, Menno M Schoonheim, Cornelis J Stam, Marieke L van der Meer, Bob W van Dijk, Frederik Barkhof, Chris H Polman, Arjan Hillebrand
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b4898cbdb5245ef8c2ee1037be4829d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b4898cbdb5245ef8c2ee1037be4829d
record_format	dspace
spelling	oai:doaj.org-article:8b4898cbdb5245ef8c2ee1037be4829d2021-11-18T09:01:52ZCognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.1932-620310.1371/journal.pone.0069318https://doaj.org/article/8b4898cbdb5245ef8c2ee1037be4829d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935983/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as thalamic atrophy and white matter lesion load, and clinical and cognitive dysfunction. Resting-state magnetoencephalography recordings from 21 MS patients and 17 gender- and age matched controls were projected onto atlas-based regions-of-interest using beamforming. Average functional connectivity was computed for each ROI and literature-based resting-state networks using the phase-lag index. Structural measures of whole brain and thalamic atrophy and lesion load were estimated from MRI scans. Global analyses showed lower functional connectivity in the alpha2 band and higher functional connectivity in the beta band in patients with Multiple Sclerosis. Additionally, alpha2 band functional connectivity was lower for the patients in two resting-state networks, namely the default mode network and the visual network. Higher beta band functional connectivity was found in the default mode network and in the temporo-parietal network. Lower alpha2 band functional connectivity in the visual network was related to lower thalamic volumes. Beta band functional connectivity correlated positively with disability scores, most prominently in the default mode network, and correlated negatively with cognitive performance in this network. These findings illustrate the relationship between thalamic atrophy, altered functional connectivity and clinical and cognitive dysfunction in MS, which could serve as a bridge to understand how neurodegeneration is associated with altered functional connectivity and subsequently clinical and cognitive decline.Prejaas TewarieMenno M SchoonheimCornelis J StamMarieke L van der MeerBob W van DijkFrederik BarkhofChris H PolmanArjan HillebrandPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69318 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Prejaas Tewarie Menno M Schoonheim Cornelis J Stam Marieke L van der Meer Bob W van Dijk Frederik Barkhof Chris H Polman Arjan Hillebrand Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
description	The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as thalamic atrophy and white matter lesion load, and clinical and cognitive dysfunction. Resting-state magnetoencephalography recordings from 21 MS patients and 17 gender- and age matched controls were projected onto atlas-based regions-of-interest using beamforming. Average functional connectivity was computed for each ROI and literature-based resting-state networks using the phase-lag index. Structural measures of whole brain and thalamic atrophy and lesion load were estimated from MRI scans. Global analyses showed lower functional connectivity in the alpha2 band and higher functional connectivity in the beta band in patients with Multiple Sclerosis. Additionally, alpha2 band functional connectivity was lower for the patients in two resting-state networks, namely the default mode network and the visual network. Higher beta band functional connectivity was found in the default mode network and in the temporo-parietal network. Lower alpha2 band functional connectivity in the visual network was related to lower thalamic volumes. Beta band functional connectivity correlated positively with disability scores, most prominently in the default mode network, and correlated negatively with cognitive performance in this network. These findings illustrate the relationship between thalamic atrophy, altered functional connectivity and clinical and cognitive dysfunction in MS, which could serve as a bridge to understand how neurodegeneration is associated with altered functional connectivity and subsequently clinical and cognitive decline.
format	article
author	Prejaas Tewarie Menno M Schoonheim Cornelis J Stam Marieke L van der Meer Bob W van Dijk Frederik Barkhof Chris H Polman Arjan Hillebrand
author_facet	Prejaas Tewarie Menno M Schoonheim Cornelis J Stam Marieke L van der Meer Bob W van Dijk Frederik Barkhof Chris H Polman Arjan Hillebrand
author_sort	Prejaas Tewarie
title	Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
title_short	Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
title_full	Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
title_fullStr	Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
title_full_unstemmed	Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
title_sort	cognitive and clinical dysfunction, altered meg resting-state networks and thalamic atrophy in multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8b4898cbdb5245ef8c2ee1037be4829d
work_keys_str_mv	AT prejaastewarie cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT mennomschoonheim cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT cornelisjstam cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT mariekelvandermeer cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT bobwvandijk cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT frederikbarkhof cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT chrishpolman cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis AT arjanhillebrand cognitiveandclinicaldysfunctionalteredmegrestingstatenetworksandthalamicatrophyinmultiplesclerosis
_version_	1718421033664380928

Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.

Ejemplares similares