Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.

<h4>Objectives</h4>To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS.<h4>Methods</h4>303 patients with MS and 279 h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martina Borghi, Marco Cavallo, Sara Carletto, Luca Ostacoli, Marco Zuffranieri, Rocco Luigi Picci, Francesco Scavelli, Harriet Johnston, Pier Maria Furlan, Antonio Bertolotto, Simona Malucchi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b4a4f22dbf84bd7bd117531df607eba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b4a4f22dbf84bd7bd117531df607eba
record_format	dspace
spelling	oai:doaj.org-article:8b4a4f22dbf84bd7bd117531df607eba2021-11-18T09:02:24ZPresence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.1932-620310.1371/journal.pone.0069820https://doaj.org/article/8b4a4f22dbf84bd7bd117531df607eba2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922813/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS.<h4>Methods</h4>303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); measures of pre-morbid verbal competence and neuropsychiatric measures were also administered.<h4>Results</h4>Patients and healthy controls were matched for age, gender, education and pre-morbid verbal Intelligence Quotient. Patients presenting with cognitive impairment were 108/303 (35.6%). In the overall group of participants, the significant predictors of the most sensitive BRB-N scores were: presence of MS, age, education, and Vocabulary. The significant predictors when considering MS patients only were: course of MS, age, education, vocabulary, and depression. Using logistic regression analyses, significant determinants of the presence of cognitive impairment in relapsing-remitting MS patients were: duration of illness (OR = 1.053, 95% CI = 1.010-1.097, p = 0.015), Expanded Disability Status Scale score (OR = 1.247, 95% CI = 1.024-1.517, p = 0.028), and vocabulary (OR = 0.960, 95% CI = 0.936-0.984, p = 0.001), while in the smaller group of progressive MS patients these predictors did not play a significant role in determining the cognitive outcome.<h4>Conclusions</h4>Our results corroborate the evidence about the presence and the nature of cognitive impairment in a large sample of patients with MS. Furthermore, our findings identify significant clinical and demographic determinants of cognitive impairment in a large sample of MS patients for the first time. Implications for further research and clinical practice were discussed.Martina BorghiMarco CavalloSara CarlettoLuca OstacoliMarco ZuffranieriRocco Luigi PicciFrancesco ScavelliHarriet JohnstonPier Maria FurlanAntonio BertolottoSimona MalucchiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69820 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martina Borghi Marco Cavallo Sara Carletto Luca Ostacoli Marco Zuffranieri Rocco Luigi Picci Francesco Scavelli Harriet Johnston Pier Maria Furlan Antonio Bertolotto Simona Malucchi Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
description	<h4>Objectives</h4>To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS.<h4>Methods</h4>303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); measures of pre-morbid verbal competence and neuropsychiatric measures were also administered.<h4>Results</h4>Patients and healthy controls were matched for age, gender, education and pre-morbid verbal Intelligence Quotient. Patients presenting with cognitive impairment were 108/303 (35.6%). In the overall group of participants, the significant predictors of the most sensitive BRB-N scores were: presence of MS, age, education, and Vocabulary. The significant predictors when considering MS patients only were: course of MS, age, education, vocabulary, and depression. Using logistic regression analyses, significant determinants of the presence of cognitive impairment in relapsing-remitting MS patients were: duration of illness (OR = 1.053, 95% CI = 1.010-1.097, p = 0.015), Expanded Disability Status Scale score (OR = 1.247, 95% CI = 1.024-1.517, p = 0.028), and vocabulary (OR = 0.960, 95% CI = 0.936-0.984, p = 0.001), while in the smaller group of progressive MS patients these predictors did not play a significant role in determining the cognitive outcome.<h4>Conclusions</h4>Our results corroborate the evidence about the presence and the nature of cognitive impairment in a large sample of patients with MS. Furthermore, our findings identify significant clinical and demographic determinants of cognitive impairment in a large sample of MS patients for the first time. Implications for further research and clinical practice were discussed.
format	article
author	Martina Borghi Marco Cavallo Sara Carletto Luca Ostacoli Marco Zuffranieri Rocco Luigi Picci Francesco Scavelli Harriet Johnston Pier Maria Furlan Antonio Bertolotto Simona Malucchi
author_facet	Martina Borghi Marco Cavallo Sara Carletto Luca Ostacoli Marco Zuffranieri Rocco Luigi Picci Francesco Scavelli Harriet Johnston Pier Maria Furlan Antonio Bertolotto Simona Malucchi
author_sort	Martina Borghi
title	Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
title_short	Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
title_full	Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
title_fullStr	Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
title_full_unstemmed	Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
title_sort	presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8b4a4f22dbf84bd7bd117531df607eba
work_keys_str_mv	AT martinaborghi presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT marcocavallo presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT saracarletto presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT lucaostacoli presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT marcozuffranieri presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT roccoluigipicci presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT francescoscavelli presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT harrietjohnston presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT piermariafurlan presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT antoniobertolotto presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis AT simonamalucchi presenceandsignificantdeterminantsofcognitiveimpairmentinalargesampleofpatientswithmultiplesclerosis
_version_	1718421033865707520

Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis.

Ejemplares similares