Brown adipose tissue in morbidly obese subjects.

<h4>Background</h4>Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to...

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Autores principales:	Guy H E J Vijgen, Nicole D Bouvy, G J Jaap Teule, Boudewijn Brans, Patrick Schrauwen, Wouter D van Marken Lichtenbelt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b4cf2d89c4e49398535f9313557b9f5
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spelling	oai:doaj.org-article:8b4cf2d89c4e49398535f9313557b9f52021-11-18T06:58:17ZBrown adipose tissue in morbidly obese subjects.1932-620310.1371/journal.pone.0017247https://doaj.org/article/8b4cf2d89c4e49398535f9313557b9f52011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21390318/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI) and body fat percentage (BF%), suggesting that obesity is associated with lower BAT activity. Here, we examined BAT activity in morbidly obese subjects and its role in cold-induced thermogenesis (CIT) after applying a personalized cooling protocol. We hypothesize that morbidly obese subjects show reduced BAT activity upon cold exposure.<h4>Methods and findings</h4>After applying a personalized cooling protocol for maximal non-shivering conditions, BAT activity was determined using positron-emission tomography and computed tomography (PET-CT). Cold-induced BAT activity was detected in three out of 15 morbidly obese subjects. Combined with results from lean to morbidly obese subjects (n = 39) from previous study, the collective data show a highly significant correlation between BAT activity and body composition (P<0.001), respectively explaining 64% and 60% of the variance in BMI (r = 0.8; P<0.001) and BF% (r = 0.75; P<0.001). Obese individuals demonstrate a blunted CIT combined with low BAT activity. Only in BAT-positive subjects (n = 26) mean energy expenditure was increased significantly upon cold exposure (51.5±6.7 J/s versus 44.0±5.1 J/s, P = 0.001), and the increase was significantly higher compared to BAT-negative subjects (+15.5±8.9% versus +3.6±8.9%, P = 0.001), indicating a role for BAT in CIT in humans.<h4>Conclusions</h4>This study shows that in an extremely large range of body compositions, BAT activity is highly correlated with BMI and BF%. BAT-positive subjects showed higher CIT, indicating that BAT is also in humans involved in adaptive thermogenesis. Increasing BAT activity could be a therapeutic target in (morbid) obesity.Guy H E J VijgenNicole D BouvyG J Jaap TeuleBoudewijn BransPatrick SchrauwenWouter D van Marken LichtenbeltPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17247 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guy H E J Vijgen Nicole D Bouvy G J Jaap Teule Boudewijn Brans Patrick Schrauwen Wouter D van Marken Lichtenbelt Brown adipose tissue in morbidly obese subjects.
description	<h4>Background</h4>Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI) and body fat percentage (BF%), suggesting that obesity is associated with lower BAT activity. Here, we examined BAT activity in morbidly obese subjects and its role in cold-induced thermogenesis (CIT) after applying a personalized cooling protocol. We hypothesize that morbidly obese subjects show reduced BAT activity upon cold exposure.<h4>Methods and findings</h4>After applying a personalized cooling protocol for maximal non-shivering conditions, BAT activity was determined using positron-emission tomography and computed tomography (PET-CT). Cold-induced BAT activity was detected in three out of 15 morbidly obese subjects. Combined with results from lean to morbidly obese subjects (n = 39) from previous study, the collective data show a highly significant correlation between BAT activity and body composition (P<0.001), respectively explaining 64% and 60% of the variance in BMI (r = 0.8; P<0.001) and BF% (r = 0.75; P<0.001). Obese individuals demonstrate a blunted CIT combined with low BAT activity. Only in BAT-positive subjects (n = 26) mean energy expenditure was increased significantly upon cold exposure (51.5±6.7 J/s versus 44.0±5.1 J/s, P = 0.001), and the increase was significantly higher compared to BAT-negative subjects (+15.5±8.9% versus +3.6±8.9%, P = 0.001), indicating a role for BAT in CIT in humans.<h4>Conclusions</h4>This study shows that in an extremely large range of body compositions, BAT activity is highly correlated with BMI and BF%. BAT-positive subjects showed higher CIT, indicating that BAT is also in humans involved in adaptive thermogenesis. Increasing BAT activity could be a therapeutic target in (morbid) obesity.
format	article
author	Guy H E J Vijgen Nicole D Bouvy G J Jaap Teule Boudewijn Brans Patrick Schrauwen Wouter D van Marken Lichtenbelt
author_facet	Guy H E J Vijgen Nicole D Bouvy G J Jaap Teule Boudewijn Brans Patrick Schrauwen Wouter D van Marken Lichtenbelt
author_sort	Guy H E J Vijgen
title	Brown adipose tissue in morbidly obese subjects.
title_short	Brown adipose tissue in morbidly obese subjects.
title_full	Brown adipose tissue in morbidly obese subjects.
title_fullStr	Brown adipose tissue in morbidly obese subjects.
title_full_unstemmed	Brown adipose tissue in morbidly obese subjects.
title_sort	brown adipose tissue in morbidly obese subjects.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8b4cf2d89c4e49398535f9313557b9f5
work_keys_str_mv	AT guyhejvijgen brownadiposetissueinmorbidlyobesesubjects AT nicoledbouvy brownadiposetissueinmorbidlyobesesubjects AT gjjaapteule brownadiposetissueinmorbidlyobesesubjects AT boudewijnbrans brownadiposetissueinmorbidlyobesesubjects AT patrickschrauwen brownadiposetissueinmorbidlyobesesubjects AT wouterdvanmarkenlichtenbelt brownadiposetissueinmorbidlyobesesubjects
_version_	1718424117094383616

Brown adipose tissue in morbidly obese subjects.

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