Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice

Muluken Walle Birhanie,1 Bizuayehu Walle,1 Kidist Rebba2 1Department of Physiology, 2Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia Background: Myrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Birhanie MW, Walle B, Rebba K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Myrtus communis hypnotic motor coordination muscle relaxation Essential oil (EO). Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/8b4e04d623c54d5c868446f85c275b52
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b4e04d623c54d5c868446f85c275b52
record_format	dspace
spelling	oai:doaj.org-article:8b4e04d623c54d5c868446f85c275b522021-12-02T05:27:15ZHypnotic effect of the essential oil from the leaves of Myrtus communis on mice1179-1608https://doaj.org/article/8b4e04d623c54d5c868446f85c275b522016-08-01T00:00:00Zhttps://www.dovepress.com/hypnotic-effect-of-the-essential-oil-from-the-leaves-of-myrtus-communi-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Muluken Walle Birhanie,1 Bizuayehu Walle,1 Kidist Rebba2 1Department of Physiology, 2Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia Background: Myrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous studies have also indicated its sedative- and hypnotic-like activity. In this study, the hypnotic effect of M. communis was investigated.Methods: Essential oil (EO) of M. communis (600, 800, and 1,000 mg/kg) was given orally to Swiss albino mice of both sex, and the hypnotic effect was evaluated. In addition, the EO of M. communis (500, 600, 800, and 1,000 mg/kg) was administered orally to Swiss albino mice of both sex 60 minutes prior to pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. The effect of the EO on motor coordination and muscle relaxation was evaluated using chimney and traction tests, 60 and 90 minutes after administration of the respective doses of the EO, respectively.Results: There was no induction of hypnosis as the presence of the righting reflex was intact. However the EO prolonged pentobarbital-induced sleeping time and there was also 50% negative response on the chimney and traction test in a dose dependent manner.Conclusion: The EO of M. communis did not produce a hypnotic effect, but it potentiated a hypnotic effect with significant central nervous system depressant activity. Keywords: Myrtus communis, hypnotic, motor coordination, muscle relaxation, essential oilBirhanie MWWalle BRebba KDove Medical PressarticleMyrtus communishypnoticmotor coordinationmuscle relaxationEssential oil (EO).PsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 8, Pp 267-275 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myrtus communis hypnotic motor coordination muscle relaxation Essential oil (EO). Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Myrtus communis hypnotic motor coordination muscle relaxation Essential oil (EO). Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Birhanie MW Walle B Rebba K Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
description	Muluken Walle Birhanie,1 Bizuayehu Walle,1 Kidist Rebba2 1Department of Physiology, 2Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia Background: Myrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous studies have also indicated its sedative- and hypnotic-like activity. In this study, the hypnotic effect of M. communis was investigated.Methods: Essential oil (EO) of M. communis (600, 800, and 1,000 mg/kg) was given orally to Swiss albino mice of both sex, and the hypnotic effect was evaluated. In addition, the EO of M. communis (500, 600, 800, and 1,000 mg/kg) was administered orally to Swiss albino mice of both sex 60 minutes prior to pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. The effect of the EO on motor coordination and muscle relaxation was evaluated using chimney and traction tests, 60 and 90 minutes after administration of the respective doses of the EO, respectively.Results: There was no induction of hypnosis as the presence of the righting reflex was intact. However the EO prolonged pentobarbital-induced sleeping time and there was also 50% negative response on the chimney and traction test in a dose dependent manner.Conclusion: The EO of M. communis did not produce a hypnotic effect, but it potentiated a hypnotic effect with significant central nervous system depressant activity. Keywords: Myrtus communis, hypnotic, motor coordination, muscle relaxation, essential oil
format	article
author	Birhanie MW Walle B Rebba K
author_facet	Birhanie MW Walle B Rebba K
author_sort	Birhanie MW
title	Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
title_short	Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
title_full	Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
title_fullStr	Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
title_full_unstemmed	Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice
title_sort	hypnotic effect of the essential oil from the leaves of myrtus communis on mice
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8b4e04d623c54d5c868446f85c275b52
work_keys_str_mv	AT birhaniemw hypnoticeffectoftheessentialoilfromtheleavesofmyrtuscommunisonmice AT walleb hypnoticeffectoftheessentialoilfromtheleavesofmyrtuscommunisonmice AT rebbak hypnoticeffectoftheessentialoilfromtheleavesofmyrtuscommunisonmice
_version_	1718400426048487424

Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice

Ejemplares similares