Genomic insights into the virulence and salt tolerance of Staphylococcus equorum

Abstract To shed light on the genetic background behind the virulence and salt tolerance of Staphylococcus equorum, we performed comparative genome analysis of six S. equorum strains. Data on four previously published genome sequences were obtained from the NCBI database, while those on strain KM103...

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Autores principales:	Do-Won Jeong, Sojeong Heo, Sangryeol Ryu, Jochen Blom, Jong-Hoon Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b4ea757dd254b39874407e0014e990e
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spelling	oai:doaj.org-article:8b4ea757dd254b39874407e0014e990e2021-12-02T16:06:40ZGenomic insights into the virulence and salt tolerance of Staphylococcus equorum10.1038/s41598-017-05918-52045-2322https://doaj.org/article/8b4ea757dd254b39874407e0014e990e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05918-5https://doaj.org/toc/2045-2322Abstract To shed light on the genetic background behind the virulence and salt tolerance of Staphylococcus equorum, we performed comparative genome analysis of six S. equorum strains. Data on four previously published genome sequences were obtained from the NCBI database, while those on strain KM1031 displaying resistance to multiple antibiotics and strain C2014 causing haemolysis were determined in this study. Examination of the pan-genome of five of the six S. equorum strains showed that the conserved core genome retained the genes for general physiological processes and survival of the species. In this comparative genomic analysis, the factors that distinguish the strains from each other, including acquired genomic factors in mobile elements, were identified. Additionally, the high salt tolerance of strains enabling growth at a NaCl concentration of 25% (w/v) was attributed to the genes encoding potassium voltage-gated channels. Among the six strains, KS1039 does not possess any of the functional virulence determinants expressed in the other strains.Do-Won JeongSojeong HeoSangryeol RyuJochen BlomJong-Hoon LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Do-Won Jeong Sojeong Heo Sangryeol Ryu Jochen Blom Jong-Hoon Lee Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
description	Abstract To shed light on the genetic background behind the virulence and salt tolerance of Staphylococcus equorum, we performed comparative genome analysis of six S. equorum strains. Data on four previously published genome sequences were obtained from the NCBI database, while those on strain KM1031 displaying resistance to multiple antibiotics and strain C2014 causing haemolysis were determined in this study. Examination of the pan-genome of five of the six S. equorum strains showed that the conserved core genome retained the genes for general physiological processes and survival of the species. In this comparative genomic analysis, the factors that distinguish the strains from each other, including acquired genomic factors in mobile elements, were identified. Additionally, the high salt tolerance of strains enabling growth at a NaCl concentration of 25% (w/v) was attributed to the genes encoding potassium voltage-gated channels. Among the six strains, KS1039 does not possess any of the functional virulence determinants expressed in the other strains.
format	article
author	Do-Won Jeong Sojeong Heo Sangryeol Ryu Jochen Blom Jong-Hoon Lee
author_facet	Do-Won Jeong Sojeong Heo Sangryeol Ryu Jochen Blom Jong-Hoon Lee
author_sort	Do-Won Jeong
title	Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
title_short	Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
title_full	Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
title_fullStr	Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
title_full_unstemmed	Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
title_sort	genomic insights into the virulence and salt tolerance of staphylococcus equorum
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8b4ea757dd254b39874407e0014e990e
work_keys_str_mv	AT dowonjeong genomicinsightsintothevirulenceandsalttoleranceofstaphylococcusequorum AT sojeongheo genomicinsightsintothevirulenceandsalttoleranceofstaphylococcusequorum AT sangryeolryu genomicinsightsintothevirulenceandsalttoleranceofstaphylococcusequorum AT jochenblom genomicinsightsintothevirulenceandsalttoleranceofstaphylococcusequorum AT jonghoonlee genomicinsightsintothevirulenceandsalttoleranceofstaphylococcusequorum
_version_	1718384913545166848

Genomic insights into the virulence and salt tolerance of Staphylococcus equorum

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