Microfluidic Systems to Study Neutrophil Forward and Reverse Migration

During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local infection and healing of the injury. Neutrophils are considered to be short-lived effector cells that undergo cell death at infection sites an...

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Autores principales:	Kehinde Adebayo Babatunde, Jose M. Ayuso, Sheena C. Kerr, Anna Huttenlocher, David J. Beebe
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neutrophils microfluidic reverse migration forward migration migration Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8b502aa1b895440dbf8c353de02d5fb8
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spelling	oai:doaj.org-article:8b502aa1b895440dbf8c353de02d5fb82021-11-30T19:45:22ZMicrofluidic Systems to Study Neutrophil Forward and Reverse Migration1664-322410.3389/fimmu.2021.781535https://doaj.org/article/8b502aa1b895440dbf8c353de02d5fb82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.781535/fullhttps://doaj.org/toc/1664-3224During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local infection and healing of the injury. Neutrophils are considered to be short-lived effector cells that undergo cell death at infection sites and in damaged tissues. However, recent in vitro and in vivo evidence suggests that neutrophil behavior is more complex and that they can migrate away from the inflammatory site back into the vasculature following the resolution of inflammation. Microfluidic devices have contributed to an improved understanding of the interaction and behavior of neutrophils ex vivo in 2D and 3D microenvironments. The role of reverse migration and its contribution to the resolution of inflammation remains unclear. In this review, we will provide a summary of the current applications of microfluidic devices to investigate neutrophil behavior and interactions with other immune cells with a focus on forward and reverse migration in neutrophils.Kehinde Adebayo BabatundeJose M. AyusoSheena C. KerrSheena C. KerrAnna HuttenlocherDavid J. BeebeDavid J. BeebeDavid J. BeebeFrontiers Media S.A.articleneutrophilsmicrofluidicreverse migrationforward migrationmigrationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophils microfluidic reverse migration forward migration migration Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophils microfluidic reverse migration forward migration migration Immunologic diseases. Allergy RC581-607 Kehinde Adebayo Babatunde Jose M. Ayuso Sheena C. Kerr Sheena C. Kerr Anna Huttenlocher David J. Beebe David J. Beebe David J. Beebe Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
description	During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local infection and healing of the injury. Neutrophils are considered to be short-lived effector cells that undergo cell death at infection sites and in damaged tissues. However, recent in vitro and in vivo evidence suggests that neutrophil behavior is more complex and that they can migrate away from the inflammatory site back into the vasculature following the resolution of inflammation. Microfluidic devices have contributed to an improved understanding of the interaction and behavior of neutrophils ex vivo in 2D and 3D microenvironments. The role of reverse migration and its contribution to the resolution of inflammation remains unclear. In this review, we will provide a summary of the current applications of microfluidic devices to investigate neutrophil behavior and interactions with other immune cells with a focus on forward and reverse migration in neutrophils.
format	article
author	Kehinde Adebayo Babatunde Jose M. Ayuso Sheena C. Kerr Sheena C. Kerr Anna Huttenlocher David J. Beebe David J. Beebe David J. Beebe
author_facet	Kehinde Adebayo Babatunde Jose M. Ayuso Sheena C. Kerr Sheena C. Kerr Anna Huttenlocher David J. Beebe David J. Beebe David J. Beebe
author_sort	Kehinde Adebayo Babatunde
title	Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
title_short	Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
title_full	Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
title_fullStr	Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
title_full_unstemmed	Microfluidic Systems to Study Neutrophil Forward and Reverse Migration
title_sort	microfluidic systems to study neutrophil forward and reverse migration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8b502aa1b895440dbf8c353de02d5fb8
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_version_	1718406276005756928

Microfluidic Systems to Study Neutrophil Forward and Reverse Migration

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