CRY2 genetic variants associate with dysthymia.

People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and...

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Autores principales:	Leena Kovanen, Mari Kaunisto, Kati Donner, Sirkku T Saarikoski, Timo Partonen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b540410fa7f4b3990d0efb0ad52c55b
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spelling	oai:doaj.org-article:8b540410fa7f4b3990d0efb0ad52c55b2021-11-18T09:00:34ZCRY2 genetic variants associate with dysthymia.1932-620310.1371/journal.pone.0071450https://doaj.org/article/8b540410fa7f4b3990d0efb0ad52c55b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23951166/?tool=EBIhttps://doaj.org/toc/1932-6203People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and anxiety disorders. Of these three genes, 48 single-nucleotide polymorphisms (SNPs) whose selection was based on the linkage disequilibrium and potential functionality were genotyped in 5910 individuals from a nationwide population-based sample. The diagnoses of major depressive disorder, dysthymia and anxiety disorders were assessed with a structured interview (M-CIDI). In addition, the participants filled in self-report questionnaires on depressive and anxiety symptoms. Logistic and linear regression models were used to analyze the associations of the SNPs with the phenotypes. Four CRY2 genetic variants (rs10838524, rs7121611, rs7945565, rs1401419) associated significantly with dysthymia (false discovery rate q<0.05). This finding together with earlier CRY2 associations with winter depression and with bipolar type 1 disorder supports the view that CRY2 gene has a role in mood disorders.Leena KovanenMari KaunistoKati DonnerSirkku T SaarikoskiTimo PartonenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71450 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leena Kovanen Mari Kaunisto Kati Donner Sirkku T Saarikoski Timo Partonen CRY2 genetic variants associate with dysthymia.
description	People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and anxiety disorders. Of these three genes, 48 single-nucleotide polymorphisms (SNPs) whose selection was based on the linkage disequilibrium and potential functionality were genotyped in 5910 individuals from a nationwide population-based sample. The diagnoses of major depressive disorder, dysthymia and anxiety disorders were assessed with a structured interview (M-CIDI). In addition, the participants filled in self-report questionnaires on depressive and anxiety symptoms. Logistic and linear regression models were used to analyze the associations of the SNPs with the phenotypes. Four CRY2 genetic variants (rs10838524, rs7121611, rs7945565, rs1401419) associated significantly with dysthymia (false discovery rate q<0.05). This finding together with earlier CRY2 associations with winter depression and with bipolar type 1 disorder supports the view that CRY2 gene has a role in mood disorders.
format	article
author	Leena Kovanen Mari Kaunisto Kati Donner Sirkku T Saarikoski Timo Partonen
author_facet	Leena Kovanen Mari Kaunisto Kati Donner Sirkku T Saarikoski Timo Partonen
author_sort	Leena Kovanen
title	CRY2 genetic variants associate with dysthymia.
title_short	CRY2 genetic variants associate with dysthymia.
title_full	CRY2 genetic variants associate with dysthymia.
title_fullStr	CRY2 genetic variants associate with dysthymia.
title_full_unstemmed	CRY2 genetic variants associate with dysthymia.
title_sort	cry2 genetic variants associate with dysthymia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8b540410fa7f4b3990d0efb0ad52c55b
work_keys_str_mv	AT leenakovanen cry2geneticvariantsassociatewithdysthymia AT marikaunisto cry2geneticvariantsassociatewithdysthymia AT katidonner cry2geneticvariantsassociatewithdysthymia AT sirkkutsaarikoski cry2geneticvariantsassociatewithdysthymia AT timopartonen cry2geneticvariantsassociatewithdysthymia
_version_	1718421034082762752

CRY2 genetic variants associate with dysthymia.

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