Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge

Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic compo...

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Autores principales:	Xiangwei Lin, Yajing Shen, Lidai Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multi-scale photoacoustic imaging hemostatic sponge chitosan–graphene oxide wound healing Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8b5c2f3a92474e30b518ed08dfe6ee0d
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spelling	oai:doaj.org-article:8b5c2f3a92474e30b518ed08dfe6ee0d2021-11-25T18:30:33ZMulti-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge10.3390/nano111128792079-4991https://doaj.org/article/8b5c2f3a92474e30b518ed08dfe6ee0d2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2879https://doaj.org/toc/2079-4991Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleeding injury experiments. Results show that the synthesized hemostatic sponge can not only absorb plasma in blood fast with its interior porous structure but also stimulate the interfacial reaction with erythrocytes and platelets. The superiority of multi-scale photoacoustic imaging for guiding, monitoring, and evaluating the hemostatic stages of sponges is demonstrated with high spatial resolution and great sensitivity at depths. Photoacoustic evaluation of a chitosan–graphene oxide-based hemostatic sponge has the potential to be transferred toward the clinical assessment of wound healing.Xiangwei LinYajing ShenLidai WangMDPI AGarticlemulti-scale photoacoustic imaginghemostatic spongechitosan–graphene oxidewound healingChemistryQD1-999ENNanomaterials, Vol 11, Iss 2879, p 2879 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multi-scale photoacoustic imaging hemostatic sponge chitosan–graphene oxide wound healing Chemistry QD1-999
spellingShingle	multi-scale photoacoustic imaging hemostatic sponge chitosan–graphene oxide wound healing Chemistry QD1-999 Xiangwei Lin Yajing Shen Lidai Wang Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
description	Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleeding injury experiments. Results show that the synthesized hemostatic sponge can not only absorb plasma in blood fast with its interior porous structure but also stimulate the interfacial reaction with erythrocytes and platelets. The superiority of multi-scale photoacoustic imaging for guiding, monitoring, and evaluating the hemostatic stages of sponges is demonstrated with high spatial resolution and great sensitivity at depths. Photoacoustic evaluation of a chitosan–graphene oxide-based hemostatic sponge has the potential to be transferred toward the clinical assessment of wound healing.
format	article
author	Xiangwei Lin Yajing Shen Lidai Wang
author_facet	Xiangwei Lin Yajing Shen Lidai Wang
author_sort	Xiangwei Lin
title	Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
title_short	Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
title_full	Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
title_fullStr	Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
title_full_unstemmed	Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
title_sort	multi-scale photoacoustic assessment of wound healing using chitosan–graphene oxide hemostatic sponge
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8b5c2f3a92474e30b518ed08dfe6ee0d
work_keys_str_mv	AT xiangweilin multiscalephotoacousticassessmentofwoundhealingusingchitosangrapheneoxidehemostaticsponge AT yajingshen multiscalephotoacousticassessmentofwoundhealingusingchitosangrapheneoxidehemostaticsponge AT lidaiwang multiscalephotoacousticassessmentofwoundhealingusingchitosangrapheneoxidehemostaticsponge
_version_	1718411089326112768

Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge

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