In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor

A one-pot three-component protocol was designed for cascade synthesis of novel heterocyclic amino-1,8-naphthyridines. Materials synthesis is confirmed by NMR (1H and 13C) and structures are verified by computational models. The in vitro phytotoxic and urease enzyme inhibition studies with IC50 range...

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Autores principales:	Muhammad Tariq Riaz, Muhammad Yaqub, Shumaila Javed, Dilshad Hussain, Muhammad Naeem Ashiq, Zahid Shafiq
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	1,8-naphthyridine urease enzyme inhibition in vitro phytotoxicity electrochemistry dna interaction Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/8b5cbe31c4d84a72899a42273fcbf8b5
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spelling	oai:doaj.org-article:8b5cbe31c4d84a72899a42273fcbf8b52021-11-04T15:00:42ZIn situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor1658-365510.1080/16583655.2021.1991718https://doaj.org/article/8b5cbe31c4d84a72899a42273fcbf8b52021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/16583655.2021.1991718https://doaj.org/toc/1658-3655A one-pot three-component protocol was designed for cascade synthesis of novel heterocyclic amino-1,8-naphthyridines. Materials synthesis is confirmed by NMR (1H and 13C) and structures are verified by computational models. The in vitro phytotoxic and urease enzyme inhibition studies with IC50 ranges from 23.76 ± 0.027 µM to 67.46 ± 3.93 indicating significant pharmacological activity of synthesized compounds. Osiris calculations results confirm the non-mutagenicity and non-irritating patterns. Molinspiration calculations values of 3.49–3.94 indicate the permeability of the derivates through membranes. Amino-1,8-naphthyridines are used for the first time in electrochemical sensing of DNA. The mechanism of interaction between DNA and amino-1,8-naphthyridine derivatives is evaluated via a constant current potentiometric method. Different electrochemical parameters such as scan rate, binding time, and effect of concentration of DNA are optimized. The strong interaction of these compounds with the human DNA under physiological conditions justified their potential applications as biosensors after further optimization.Muhammad Tariq RiazMuhammad YaqubShumaila JavedDilshad HussainMuhammad Naeem AshiqZahid ShafiqTaylor & Francis Grouparticle1,8-naphthyridineurease enzyme inhibitionin vitro phytotoxicityelectrochemistrydna interactionScience (General)Q1-390ENJournal of Taibah University for Science, Vol 15, Iss 1, Pp 559-566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	1,8-naphthyridine urease enzyme inhibition in vitro phytotoxicity electrochemistry dna interaction Science (General) Q1-390
spellingShingle	1,8-naphthyridine urease enzyme inhibition in vitro phytotoxicity electrochemistry dna interaction Science (General) Q1-390 Muhammad Tariq Riaz Muhammad Yaqub Shumaila Javed Dilshad Hussain Muhammad Naeem Ashiq Zahid Shafiq In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
description	A one-pot three-component protocol was designed for cascade synthesis of novel heterocyclic amino-1,8-naphthyridines. Materials synthesis is confirmed by NMR (1H and 13C) and structures are verified by computational models. The in vitro phytotoxic and urease enzyme inhibition studies with IC50 ranges from 23.76 ± 0.027 µM to 67.46 ± 3.93 indicating significant pharmacological activity of synthesized compounds. Osiris calculations results confirm the non-mutagenicity and non-irritating patterns. Molinspiration calculations values of 3.49–3.94 indicate the permeability of the derivates through membranes. Amino-1,8-naphthyridines are used for the first time in electrochemical sensing of DNA. The mechanism of interaction between DNA and amino-1,8-naphthyridine derivatives is evaluated via a constant current potentiometric method. Different electrochemical parameters such as scan rate, binding time, and effect of concentration of DNA are optimized. The strong interaction of these compounds with the human DNA under physiological conditions justified their potential applications as biosensors after further optimization.
format	article
author	Muhammad Tariq Riaz Muhammad Yaqub Shumaila Javed Dilshad Hussain Muhammad Naeem Ashiq Zahid Shafiq
author_facet	Muhammad Tariq Riaz Muhammad Yaqub Shumaila Javed Dilshad Hussain Muhammad Naeem Ashiq Zahid Shafiq
author_sort	Muhammad Tariq Riaz
title	In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
title_short	In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
title_full	In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
title_fullStr	In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
title_full_unstemmed	In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor
title_sort	in situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as dna-electrochemical biosensor
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/8b5cbe31c4d84a72899a42273fcbf8b5
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In situ evaluation of the biological active poly functionalized novel amino-1,8-naphthyridine derivatives as DNA-electrochemical biosensor

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