Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder

Abstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait...

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Autores principales:	Chun Il Park, Hae Won Kim, Syung Shick Hwang, Jee In Kang, Se Joo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b5d553cd7344cb48e1d9d59c372b6d0
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spelling	oai:doaj.org-article:8b5d553cd7344cb48e1d9d59c372b6d02021-12-02T18:02:06ZGenetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder10.1038/s41598-021-98032-62045-2322https://doaj.org/article/8b5d553cd7344cb48e1d9d59c372b6d02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98032-6https://doaj.org/toc/2045-2322Abstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait resilience in male patients with AUD. In addition, allele-specific associations between FKBP5 DNA methylation and resilience were examined. In total, 297 men with AUD were assessed for alcohol use severity, childhood trauma, resilience, and impulsivity. Genotyping for FKBP5 rs1360780 and DNA methylation were analyzed. The effects of the rs1360780 single nucleotide polymorphism (SNP) and clinical variables on resilience were tested using linear regression analysis. Possible associations between FKBP5 DNA methylation and resilience were tested with partial correlation analysis. The rs1360780 risk allele, a low education level, and high impulsivity were associated with diminished resilience, whereas no significant main or interaction effect of childhood trauma with the SNP rs1360780 genotype on resilience was shown. No significant association between FKBP5 DNA methylation and resilience was found. The present study demonstrated the involvement of the rs1360780 risk allele in trait resilience in men with AUD, suggesting that the genetic vulnerability of FKBP5 may influence resilience related to AUD.Chun Il ParkHae Won KimSyung Shick HwangJee In KangSe Joo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
description	Abstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait resilience in male patients with AUD. In addition, allele-specific associations between FKBP5 DNA methylation and resilience were examined. In total, 297 men with AUD were assessed for alcohol use severity, childhood trauma, resilience, and impulsivity. Genotyping for FKBP5 rs1360780 and DNA methylation were analyzed. The effects of the rs1360780 single nucleotide polymorphism (SNP) and clinical variables on resilience were tested using linear regression analysis. Possible associations between FKBP5 DNA methylation and resilience were tested with partial correlation analysis. The rs1360780 risk allele, a low education level, and high impulsivity were associated with diminished resilience, whereas no significant main or interaction effect of childhood trauma with the SNP rs1360780 genotype on resilience was shown. No significant association between FKBP5 DNA methylation and resilience was found. The present study demonstrated the involvement of the rs1360780 risk allele in trait resilience in men with AUD, suggesting that the genetic vulnerability of FKBP5 may influence resilience related to AUD.
format	article
author	Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim
author_facet	Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim
author_sort	Chun Il Park
title	Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
title_short	Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
title_full	Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
title_fullStr	Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
title_full_unstemmed	Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
title_sort	genetic association of fkbp5 with trait resilience in korean male patients with alcohol use disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b5d553cd7344cb48e1d9d59c372b6d0
work_keys_str_mv	AT chunilpark geneticassociationoffkbp5withtraitresilienceinkoreanmalepatientswithalcoholusedisorder AT haewonkim geneticassociationoffkbp5withtraitresilienceinkoreanmalepatientswithalcoholusedisorder AT syungshickhwang geneticassociationoffkbp5withtraitresilienceinkoreanmalepatientswithalcoholusedisorder AT jeeinkang geneticassociationoffkbp5withtraitresilienceinkoreanmalepatientswithalcoholusedisorder AT sejookim geneticassociationoffkbp5withtraitresilienceinkoreanmalepatientswithalcoholusedisorder
_version_	1718378939293892608

Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder

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