Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles...

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Autores principales: Funsho Ogunshola, Gursev Anmole, Rachel L. Miller, Emily Goering, Thandeka Nkosi, Daniel Muema, Jaclyn Mann, Nasreen Ismail, Denis Chopera, Thumbi Ndung’u, Mark A. Brockman, Zaza M Ndhlovu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e
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spelling oai:doaj.org-article:8b5dac89542c4c2da2cce8fc2d1bce1e2021-12-02T14:39:07ZDual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants10.1038/s41467-018-07209-72041-1723https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07209-7https://doaj.org/toc/2041-1723Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral controlFunsho OgunsholaGursev AnmoleRachel L. MillerEmily GoeringThandeka NkosiDaniel MuemaJaclyn MannNasreen IsmailDenis ChoperaThumbi Ndung’uMark A. BrockmanZaza M NdhlovuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Funsho Ogunshola
Gursev Anmole
Rachel L. Miller
Emily Goering
Thandeka Nkosi
Daniel Muema
Jaclyn Mann
Nasreen Ismail
Denis Chopera
Thumbi Ndung’u
Mark A. Brockman
Zaza M Ndhlovu
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
description Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral control
format article
author Funsho Ogunshola
Gursev Anmole
Rachel L. Miller
Emily Goering
Thandeka Nkosi
Daniel Muema
Jaclyn Mann
Nasreen Ismail
Denis Chopera
Thumbi Ndung’u
Mark A. Brockman
Zaza M Ndhlovu
author_facet Funsho Ogunshola
Gursev Anmole
Rachel L. Miller
Emily Goering
Thandeka Nkosi
Daniel Muema
Jaclyn Mann
Nasreen Ismail
Denis Chopera
Thumbi Ndung’u
Mark A. Brockman
Zaza M Ndhlovu
author_sort Funsho Ogunshola
title Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
title_short Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
title_full Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
title_fullStr Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
title_full_unstemmed Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
title_sort dual hla b*42 and b*81-reactive t cell receptors recognize more diverse hiv-1 gag escape variants
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e
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