On genetic specificity in symbiont-mediated host-parasite coevolution.

Existing theory of host-parasite interactions has identified the genetic specificity of interaction as a key variable affecting the outcome of coevolution. The Matching Alleles (MA) and Gene For Gene (GFG) models have been extensively studied as the canonical examples of specific and non-specific in...

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Autores principales:	Marek Kwiatkowski, Jan Engelstädter, Christoph Vorburger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b60ffcda9d34fd58d9fcc987d08b319
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spelling	oai:doaj.org-article:8b60ffcda9d34fd58d9fcc987d08b3192021-11-18T05:51:02ZOn genetic specificity in symbiont-mediated host-parasite coevolution.1553-734X1553-735810.1371/journal.pcbi.1002633https://doaj.org/article/8b60ffcda9d34fd58d9fcc987d08b3192012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22956894/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Existing theory of host-parasite interactions has identified the genetic specificity of interaction as a key variable affecting the outcome of coevolution. The Matching Alleles (MA) and Gene For Gene (GFG) models have been extensively studied as the canonical examples of specific and non-specific interaction. The generality of these models has recently been challenged by uncovering real-world host-parasite systems exhibiting specificity patterns that fit neither MA nor GFG, and by the discovery of symbiotic bacteria protecting insect hosts against parasites. In the present paper we address both challenges, simulating a large number of non-canonical models of host-parasite interactions that explicitly incorporate symbiont-based host resistance. To assess the genetic specialisation in these hybrid models, we develop a quantitative index of specificity applicable to any coevolutionary model based on a fitness matrix. We find qualitative and quantitative effects of host-parasite and symbiont-parasite specificities on genotype frequency dynamics, allele survival, and mean host and parasite fitnesses.Marek KwiatkowskiJan EngelstädterChristoph VorburgerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 8, p e1002633 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marek Kwiatkowski Jan Engelstädter Christoph Vorburger On genetic specificity in symbiont-mediated host-parasite coevolution.
description	Existing theory of host-parasite interactions has identified the genetic specificity of interaction as a key variable affecting the outcome of coevolution. The Matching Alleles (MA) and Gene For Gene (GFG) models have been extensively studied as the canonical examples of specific and non-specific interaction. The generality of these models has recently been challenged by uncovering real-world host-parasite systems exhibiting specificity patterns that fit neither MA nor GFG, and by the discovery of symbiotic bacteria protecting insect hosts against parasites. In the present paper we address both challenges, simulating a large number of non-canonical models of host-parasite interactions that explicitly incorporate symbiont-based host resistance. To assess the genetic specialisation in these hybrid models, we develop a quantitative index of specificity applicable to any coevolutionary model based on a fitness matrix. We find qualitative and quantitative effects of host-parasite and symbiont-parasite specificities on genotype frequency dynamics, allele survival, and mean host and parasite fitnesses.
format	article
author	Marek Kwiatkowski Jan Engelstädter Christoph Vorburger
author_facet	Marek Kwiatkowski Jan Engelstädter Christoph Vorburger
author_sort	Marek Kwiatkowski
title	On genetic specificity in symbiont-mediated host-parasite coevolution.
title_short	On genetic specificity in symbiont-mediated host-parasite coevolution.
title_full	On genetic specificity in symbiont-mediated host-parasite coevolution.
title_fullStr	On genetic specificity in symbiont-mediated host-parasite coevolution.
title_full_unstemmed	On genetic specificity in symbiont-mediated host-parasite coevolution.
title_sort	on genetic specificity in symbiont-mediated host-parasite coevolution.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8b60ffcda9d34fd58d9fcc987d08b319
work_keys_str_mv	AT marekkwiatkowski ongeneticspecificityinsymbiontmediatedhostparasitecoevolution AT janengelstadter ongeneticspecificityinsymbiontmediatedhostparasitecoevolution AT christophvorburger ongeneticspecificityinsymbiontmediatedhostparasitecoevolution
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On genetic specificity in symbiont-mediated host-parasite coevolution.

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