Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains

The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain bou...

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Autores principales:	Amanda Khoury, Joanna Achinger-Kawecka, Saul A. Bert, Grady C. Smith, Hugh J. French, Phuc-Loi Luu, Timothy J. Peters, Qian Du, Aled J. Parry, Fatima Valdes-Mora, Phillippa C. Taberlay, Clare Stirzaker, Aaron L. Statham, Susan J. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b6198ec146c403090e434c6de6028fa
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spelling	oai:doaj.org-article:8b6198ec146c403090e434c6de6028fa2021-12-02T14:40:51ZConstitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains10.1038/s41467-019-13753-72041-1723https://doaj.org/article/8b6198ec146c403090e434c6de6028fa2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13753-7https://doaj.org/toc/2041-1723The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain boundaries and chromatin loops constitutive to all cell types.Amanda KhouryJoanna Achinger-KaweckaSaul A. BertGrady C. SmithHugh J. FrenchPhuc-Loi LuuTimothy J. PetersQian DuAled J. ParryFatima Valdes-MoraPhillippa C. TaberlayClare StirzakerAaron L. StathamSusan J. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amanda Khoury Joanna Achinger-Kawecka Saul A. Bert Grady C. Smith Hugh J. French Phuc-Loi Luu Timothy J. Peters Qian Du Aled J. Parry Fatima Valdes-Mora Phillippa C. Taberlay Clare Stirzaker Aaron L. Statham Susan J. Clark Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
description	The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain boundaries and chromatin loops constitutive to all cell types.
format	article
author	Amanda Khoury Joanna Achinger-Kawecka Saul A. Bert Grady C. Smith Hugh J. French Phuc-Loi Luu Timothy J. Peters Qian Du Aled J. Parry Fatima Valdes-Mora Phillippa C. Taberlay Clare Stirzaker Aaron L. Statham Susan J. Clark
author_facet	Amanda Khoury Joanna Achinger-Kawecka Saul A. Bert Grady C. Smith Hugh J. French Phuc-Loi Luu Timothy J. Peters Qian Du Aled J. Parry Fatima Valdes-Mora Phillippa C. Taberlay Clare Stirzaker Aaron L. Statham Susan J. Clark
author_sort	Amanda Khoury
title	Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
title_short	Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
title_full	Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
title_fullStr	Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
title_full_unstemmed	Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
title_sort	constitutively bound ctcf sites maintain 3d chromatin architecture and long-range epigenetically regulated domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8b6198ec146c403090e434c6de6028fa
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Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains

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