Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells

The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.

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Autores principales:	Emre Balta, Robert Hardt, Jie Liang, Henning Kirchgessner, Christian Orlik, Beate Jahraus, Stefan Hillmer, Stefan Meuer, Katrin Hübner, Guido H. Wabnitz, Yvonne Samstag
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b621a4da982404ea9eb051bd47834de
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spelling	oai:doaj.org-article:8b621a4da982404ea9eb051bd47834de2021-12-02T14:38:38ZSpatial oxidation of L-plastin downmodulates actin-based functions of tumor cells10.1038/s41467-019-11909-z2041-1723https://doaj.org/article/8b621a4da982404ea9eb051bd47834de2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11909-zhttps://doaj.org/toc/2041-1723The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.Emre BaltaRobert HardtJie LiangHenning KirchgessnerChristian OrlikBeate JahrausStefan HillmerStefan MeuerKatrin HübnerGuido H. WabnitzYvonne SamstagNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emre Balta Robert Hardt Jie Liang Henning Kirchgessner Christian Orlik Beate Jahraus Stefan Hillmer Stefan Meuer Katrin Hübner Guido H. Wabnitz Yvonne Samstag Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
description	The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.
format	article
author	Emre Balta Robert Hardt Jie Liang Henning Kirchgessner Christian Orlik Beate Jahraus Stefan Hillmer Stefan Meuer Katrin Hübner Guido H. Wabnitz Yvonne Samstag
author_facet	Emre Balta Robert Hardt Jie Liang Henning Kirchgessner Christian Orlik Beate Jahraus Stefan Hillmer Stefan Meuer Katrin Hübner Guido H. Wabnitz Yvonne Samstag
author_sort	Emre Balta
title	Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
title_short	Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
title_full	Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
title_fullStr	Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
title_full_unstemmed	Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
title_sort	spatial oxidation of l-plastin downmodulates actin-based functions of tumor cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8b621a4da982404ea9eb051bd47834de
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_version_	1718390906403422208

Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells

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