A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells

Unlike transcriptional regulation of hESC identity, little is known post-transcriptionally. Here, the authors show that the RNA binding protein CSDE1 regulates core components of hESC identity, neurectoderm commitment and neurogenesis to maintain pluripotency and prevent neural differentiation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyun Ju Lee, Deniz Bartsch, Cally Xiao, Santiago Guerrero, Gaurav Ahuja, Christina Schindler, James J. Moresco, John R. Yates, Fátima Gebauer, Hisham Bazzi, Christoph Dieterich, Leo Kurian, David Vilchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b637ecfb83f4e0ea34de34086340b09
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b637ecfb83f4e0ea34de34086340b09
record_format	dspace
spelling	oai:doaj.org-article:8b637ecfb83f4e0ea34de34086340b092021-12-02T14:41:19ZA post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells10.1038/s41467-017-01744-52041-1723https://doaj.org/article/8b637ecfb83f4e0ea34de34086340b092017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01744-5https://doaj.org/toc/2041-1723Unlike transcriptional regulation of hESC identity, little is known post-transcriptionally. Here, the authors show that the RNA binding protein CSDE1 regulates core components of hESC identity, neurectoderm commitment and neurogenesis to maintain pluripotency and prevent neural differentiation.Hyun Ju LeeDeniz BartschCally XiaoSantiago GuerreroGaurav AhujaChristina SchindlerJames J. MorescoJohn R. YatesFátima GebauerHisham BazziChristoph DieterichLeo KurianDavid VilchezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyun Ju Lee Deniz Bartsch Cally Xiao Santiago Guerrero Gaurav Ahuja Christina Schindler James J. Moresco John R. Yates Fátima Gebauer Hisham Bazzi Christoph Dieterich Leo Kurian David Vilchez A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
description	Unlike transcriptional regulation of hESC identity, little is known post-transcriptionally. Here, the authors show that the RNA binding protein CSDE1 regulates core components of hESC identity, neurectoderm commitment and neurogenesis to maintain pluripotency and prevent neural differentiation.
format	article
author	Hyun Ju Lee Deniz Bartsch Cally Xiao Santiago Guerrero Gaurav Ahuja Christina Schindler James J. Moresco John R. Yates Fátima Gebauer Hisham Bazzi Christoph Dieterich Leo Kurian David Vilchez
author_facet	Hyun Ju Lee Deniz Bartsch Cally Xiao Santiago Guerrero Gaurav Ahuja Christina Schindler James J. Moresco John R. Yates Fátima Gebauer Hisham Bazzi Christoph Dieterich Leo Kurian David Vilchez
author_sort	Hyun Ju Lee
title	A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
title_short	A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
title_full	A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
title_fullStr	A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
title_full_unstemmed	A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
title_sort	post-transcriptional program coordinated by csde1 prevents intrinsic neural differentiation of human embryonic stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8b637ecfb83f4e0ea34de34086340b09
work_keys_str_mv	AT hyunjulee aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT denizbartsch aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT callyxiao aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT santiagoguerrero aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT gauravahuja aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT christinaschindler aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT jamesjmoresco aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT johnryates aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT fatimagebauer aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT hishambazzi aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT christophdieterich aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT leokurian aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT davidvilchez aposttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT hyunjulee posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT denizbartsch posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT callyxiao posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT santiagoguerrero posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT gauravahuja posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT christinaschindler posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT jamesjmoresco posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT johnryates posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT fatimagebauer posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT hishambazzi posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT christophdieterich posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT leokurian posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells AT davidvilchez posttranscriptionalprogramcoordinatedbycsde1preventsintrinsicneuraldifferentiationofhumanembryonicstemcells
_version_	1718389942657220608

A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells

Ejemplares similares