Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery
Abstract In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with tempora...
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2021
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oai:doaj.org-article:8b6477dc9dd644cca50b5342f8d037592021-12-02T16:53:00ZWada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery10.1038/s41598-021-90376-32045-2322https://doaj.org/article/8b6477dc9dd644cca50b5342f8d037592021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90376-3https://doaj.org/toc/2045-2322Abstract In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R 2 = 0.233, p = .032) and verbal memory function (∆R 2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.Nadine ConradiFriederike RosenbergSusanne KnakeLouise BiermannAnja HaagIris GornyAnke HermsenViola von PodewilsMarion BehrensMarianna GurschiRichard du Mesnil de RochemontKatja MenzlerSebastian BauerSusanne Schubert-BastChristopher NimskyJürgen KonczallaFelix RosenowAdam StrzelczykNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Nadine Conradi Friederike Rosenberg Susanne Knake Louise Biermann Anja Haag Iris Gorny Anke Hermsen Viola von Podewils Marion Behrens Marianna Gurschi Richard du Mesnil de Rochemont Katja Menzler Sebastian Bauer Susanne Schubert-Bast Christopher Nimsky Jürgen Konczalla Felix Rosenow Adam Strzelczyk Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| description |
Abstract In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R 2 = 0.233, p = .032) and verbal memory function (∆R 2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications. |
| format |
article |
| author |
Nadine Conradi Friederike Rosenberg Susanne Knake Louise Biermann Anja Haag Iris Gorny Anke Hermsen Viola von Podewils Marion Behrens Marianna Gurschi Richard du Mesnil de Rochemont Katja Menzler Sebastian Bauer Susanne Schubert-Bast Christopher Nimsky Jürgen Konczalla Felix Rosenow Adam Strzelczyk |
| author_facet |
Nadine Conradi Friederike Rosenberg Susanne Knake Louise Biermann Anja Haag Iris Gorny Anke Hermsen Viola von Podewils Marion Behrens Marianna Gurschi Richard du Mesnil de Rochemont Katja Menzler Sebastian Bauer Susanne Schubert-Bast Christopher Nimsky Jürgen Konczalla Felix Rosenow Adam Strzelczyk |
| author_sort |
Nadine Conradi |
| title |
Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| title_short |
Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| title_full |
Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| title_fullStr |
Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| title_full_unstemmed |
Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| title_sort |
wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8b6477dc9dd644cca50b5342f8d03759 |
| work_keys_str_mv |
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