Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study

JR Valdiz&aacute;n-Us&oacute;n,1 A C&aacute;novas-Mart&iacute;nez,2 MT De Lucas-Taracena,3 F D&iacute;az-Atienza,4 LS Eddy-Ives,5 A Fern&aacute;ndez-Ja&eacute;n,6 M Fern&aacute;ndez-P&eacute;rez,7 M Garc&iacute;a-Giral,8...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Valdiz&aacute;n-Us&oacute;n JR, C&aacute;novas-Mart&iacute;nez A, De Lucas-Taracena M, D&iacute;az-Atienza F, Eddy-Ives LS, Fern&aacute;ndez-Ja&eacute;n A, Fern&aacute;ndez-P&eacute;rez M, Garc&iacute;a-Giral M, Garc&iacute;a-Mag&aacute;n P, Garraus-Oneca M, Idiaz&aacute;bal-Alecha MA, L&oacute;pez-Benito M, Lorenzo-Sanz G, Mart&iacute;nez-Ant&oacute;n J, Mart&iacute;nez-Granero MA, Monta&ntilde;&eacute;s-Rada F, Mulas-Delgado F, Ochando-Perales G, Ortega-Garc&iacute;a E, Pelaz-Antol&iacute;n A, Ramos-Quiroga JA, Ruiz-Sanz FC, Vaquerizo-Madrid J, Yusta-Izquierdo A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8b681678684c4f41861cbfafc5e7256b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b681678684c4f41861cbfafc5e7256b
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Valdiz&aacute;n-Us&oacute;n JR C&aacute;novas-Mart&iacute;nez A De Lucas-Taracena M D&iacute;az-Atienza F Eddy-Ives LS Fern&aacute;ndez-Ja&eacute;n A Fern&aacute;ndez-P&eacute;rez M Garc&iacute;a-Giral M Garc&iacute;a-Mag&aacute;n P Garraus-Oneca M Idiaz&aacute;bal-Alecha MA L&oacute;pez-Benito M Lorenzo-Sanz G Mart&iacute;nez-Ant&oacute;n J Mart&iacute;nez-Granero MA Monta&ntilde;&eacute;s-Rada F Mulas-Delgado F Ochando-Perales G Ortega-Garc&iacute;a E Pelaz-Antol&iacute;n A Ramos-Quiroga JA Ruiz-Sanz FC Vaquerizo-Madrid J Yusta-Izquierdo A Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
description	JR Valdiz&aacute;n-Us&oacute;n,1 A C&aacute;novas-Mart&iacute;nez,2 MT De Lucas-Taracena,3 F D&iacute;az-Atienza,4 LS Eddy-Ives,5 A Fern&aacute;ndez-Ja&eacute;n,6 M Fern&aacute;ndez-P&eacute;rez,7 M Garc&iacute;a-Giral,8 P Garc&iacute;a-Mag&aacute;n,9 M Garraus-Oneca,10 MA Idiaz&aacute;bal-Alecha,11 M L&oacute;pez-Benito,12 G Lorenzo-Sanz,13 J Mart&iacute;nez-Ant&oacute;n,14 MA Mart&iacute;nez-Granero,15 F Monta&ntilde;&eacute;s-Rada,16 F Mulas-Delgado,17 G Ochando-Perales,18 E Ortega-Garc&iacute;a,19 A Pelaz-Antol&iacute;n,20 JA Ramos-Quiroga,21 FC Ruiz-Sanz,22 J Vaquerizo-Madrid,23 A Yusta-Izquierdo241Unidad Trastornos Neurofuncionales, Cl&iacute;nica Montpellier, Zaragoza, 2Hospital Dr Peset, Valencia, 3Hospital 12 de Octubre, Madrid, 4Hospital Virgen de las Nieves, Granada, 5Centre M&egrave;dic Sant Ramon, Santa Coloma de Gramenet, Barcelona, 6Hospital Universitario Quir&oacute;n, Madrid, 7Centro de Salud La Felguera, Langreo, Asturias, 8Hospital Cl&iacute;nic, Barcelona, 9Unidad Salud Mental, Talavera de la Reina, 10Cl&iacute;nica Universitaria de Navarra, Pamplona, 11Hospital Ntra. Sra. del Pilar, Barcelona, 12Centro Salud Contrueces, Gij&oacute;n, 13Hospital Ram&oacute;n y Cajal, Madrid, 14Complejo Hospitalario Carlos Haya, M&aacute;laga, 15Hospital Universitario Fundaci&oacute;n Alcorc&oacute;n, Alcorc&oacute;n, Madrid, 16Hospital Universitario Fundaci&oacute;n Alcorc&oacute;n, Alcorc&oacute;n, Madrid, 17Hospital Universitario La Fe, Valencia, 18Hospital Universitario La Fe, Valencia, 19Complejo Asistencial Universitario de Le&oacute;n, 20Centro Salud Mental, Alcal&aacute; de Henares, 21Hospital Universitari Vall d&#39;Hebron. CIBERSAM. Department of Psychiatry and Legal Medicine. Universitat Aut&ograve;noma de Barcelona, 22Hospital General Rio Carri&oacute;n, Palencia, 23Hospital Materno-Infantil, Badajoz, 24Hospital Universitario, Guadalajara, SpainBackground: The purpose of this multicenter Spanish study was to evaluate the response to immediate-release methylphenidate by children and adults diagnosed with attention-deficit/hyperactivity disorder (ADHD), as well as to obtain information on current therapy patterns and safety characteristics.Methods: This multicenter, observational, retrospective, noninterventional study included 730 patients aged 4&ndash;65 years with a diagnosis of ADHD. Information was obtained based on a review of medical records for the years 2002&ndash;2006 in sequential order.Results: The ADHD predominantly inattentive subtype affected 29.7% of patients, ADHD predominantly hyperactive-impulsive was found in 5.2%, and the combined subtype in 65.1%. Overall, a significant lower Clinical Global Impression (CGI) score and mean number of DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision) symptoms by subtype were found after one year of treatment with immediate-release methylphenidate; CGI decreased from 4.51 to 1.69, symptoms of inattention from 7.90 to 4.34, symptoms of hyperactivity from 6.73 to 3.39, and combined subtype symptoms from 14.62 to 7.7. Satisfaction with immediate-release methylphenidate after one year was evaluated as &ldquo;very satisfied&rdquo; or &ldquo;satisfied&rdquo; by 86.90% of the sample; 25.75% of all patients reported at least one adverse effect. At the end of the study, 41.47% of all the patients treated with immediate-release methylphenidate were still receiving it, with a mean time of 3.80 years on therapy.Conclusion: Good efficacy and safety results were found for immediate-release methylphenidate in patients with ADHD.Keywords: attention deficit hyperactivity disorder, ADHD, pharmacologic treatment, methylphenidate, satisfaction
format	article
author	Valdiz&aacute;n-Us&oacute;n JR C&aacute;novas-Mart&iacute;nez A De Lucas-Taracena M D&iacute;az-Atienza F Eddy-Ives LS Fern&aacute;ndez-Ja&eacute;n A Fern&aacute;ndez-P&eacute;rez M Garc&iacute;a-Giral M Garc&iacute;a-Mag&aacute;n P Garraus-Oneca M Idiaz&aacute;bal-Alecha MA L&oacute;pez-Benito M Lorenzo-Sanz G Mart&iacute;nez-Ant&oacute;n J Mart&iacute;nez-Granero MA Monta&ntilde;&eacute;s-Rada F Mulas-Delgado F Ochando-Perales G Ortega-Garc&iacute;a E Pelaz-Antol&iacute;n A Ramos-Quiroga JA Ruiz-Sanz FC Vaquerizo-Madrid J Yusta-Izquierdo A
author_facet	Valdiz&aacute;n-Us&oacute;n JR C&aacute;novas-Mart&iacute;nez A De Lucas-Taracena M D&iacute;az-Atienza F Eddy-Ives LS Fern&aacute;ndez-Ja&eacute;n A Fern&aacute;ndez-P&eacute;rez M Garc&iacute;a-Giral M Garc&iacute;a-Mag&aacute;n P Garraus-Oneca M Idiaz&aacute;bal-Alecha MA L&oacute;pez-Benito M Lorenzo-Sanz G Mart&iacute;nez-Ant&oacute;n J Mart&iacute;nez-Granero MA Monta&ntilde;&eacute;s-Rada F Mulas-Delgado F Ochando-Perales G Ortega-Garc&iacute;a E Pelaz-Antol&iacute;n A Ramos-Quiroga JA Ruiz-Sanz FC Vaquerizo-Madrid J Yusta-Izquierdo A
author_sort	Valdiz&aacute;n-Us&oacute;n JR
title	Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
title_short	Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
title_full	Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
title_fullStr	Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
title_full_unstemmed	Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study
title_sort	response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the spanish multicenter dihana study
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/8b681678684c4f41861cbfafc5e7256b
work_keys_str_mv	AT valdizampaacutenusampoacutenjr responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT campaacutenovasmartampiacuteneza responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT delucastaracenam responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT dampiacuteazatienzaf responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT eddyivesls responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT fernampaacutendezjaampeacutena responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT fernampaacutendezpampeacuterezm responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT garcampiacuteagiralm responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT garcampiacuteamagampaacutenp responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT garrausonecam responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT idiazampaacutebalalechama responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT lampoacutepezbenitom responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT lorenzosanzg responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT martampiacutenezantampoacutenj responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT martampiacutenezgraneroma responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT montaampntildeampeacutesradaf responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT mulasdelgadof responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT ochandoperalesg responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT ortegagarcampiacuteae responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT pelazantolampiacutena responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT ramosquirogaja responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT ruizsanzfc responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT vaquerizomadridj responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy AT yustaizquierdoa responsetomethylphenidatebyadultandpediatricpatientswithattentiondeficithyperactivitydisorderthespanishmulticenterdihanastudy
_version_	1718401503049285632
spelling	oai:doaj.org-article:8b681678684c4f41861cbfafc5e7256b2021-12-02T04:02:35ZResponse to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study1176-63281178-2021https://doaj.org/article/8b681678684c4f41861cbfafc5e7256b2013-02-01T00:00:00Zhttp://www.dovepress.com/response-to-methylphenidate-by-adult-and-pediatric-patients-with-atten-a12163https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021JR Valdiz&aacute;n-Us&oacute;n,1 A C&aacute;novas-Mart&iacute;nez,2 MT De Lucas-Taracena,3 F D&iacute;az-Atienza,4 LS Eddy-Ives,5 A Fern&aacute;ndez-Ja&eacute;n,6 M Fern&aacute;ndez-P&eacute;rez,7 M Garc&iacute;a-Giral,8 P Garc&iacute;a-Mag&aacute;n,9 M Garraus-Oneca,10 MA Idiaz&aacute;bal-Alecha,11 M L&oacute;pez-Benito,12 G Lorenzo-Sanz,13 J Mart&iacute;nez-Ant&oacute;n,14 MA Mart&iacute;nez-Granero,15 F Monta&ntilde;&eacute;s-Rada,16 F Mulas-Delgado,17 G Ochando-Perales,18 E Ortega-Garc&iacute;a,19 A Pelaz-Antol&iacute;n,20 JA Ramos-Quiroga,21 FC Ruiz-Sanz,22 J Vaquerizo-Madrid,23 A Yusta-Izquierdo241Unidad Trastornos Neurofuncionales, Cl&iacute;nica Montpellier, Zaragoza, 2Hospital Dr Peset, Valencia, 3Hospital 12 de Octubre, Madrid, 4Hospital Virgen de las Nieves, Granada, 5Centre M&egrave;dic Sant Ramon, Santa Coloma de Gramenet, Barcelona, 6Hospital Universitario Quir&oacute;n, Madrid, 7Centro de Salud La Felguera, Langreo, Asturias, 8Hospital Cl&iacute;nic, Barcelona, 9Unidad Salud Mental, Talavera de la Reina, 10Cl&iacute;nica Universitaria de Navarra, Pamplona, 11Hospital Ntra. Sra. del Pilar, Barcelona, 12Centro Salud Contrueces, Gij&oacute;n, 13Hospital Ram&oacute;n y Cajal, Madrid, 14Complejo Hospitalario Carlos Haya, M&aacute;laga, 15Hospital Universitario Fundaci&oacute;n Alcorc&oacute;n, Alcorc&oacute;n, Madrid, 16Hospital Universitario Fundaci&oacute;n Alcorc&oacute;n, Alcorc&oacute;n, Madrid, 17Hospital Universitario La Fe, Valencia, 18Hospital Universitario La Fe, Valencia, 19Complejo Asistencial Universitario de Le&oacute;n, 20Centro Salud Mental, Alcal&aacute; de Henares, 21Hospital Universitari Vall d&#39;Hebron. CIBERSAM. Department of Psychiatry and Legal Medicine. Universitat Aut&ograve;noma de Barcelona, 22Hospital General Rio Carri&oacute;n, Palencia, 23Hospital Materno-Infantil, Badajoz, 24Hospital Universitario, Guadalajara, SpainBackground: The purpose of this multicenter Spanish study was to evaluate the response to immediate-release methylphenidate by children and adults diagnosed with attention-deficit/hyperactivity disorder (ADHD), as well as to obtain information on current therapy patterns and safety characteristics.Methods: This multicenter, observational, retrospective, noninterventional study included 730 patients aged 4&ndash;65 years with a diagnosis of ADHD. Information was obtained based on a review of medical records for the years 2002&ndash;2006 in sequential order.Results: The ADHD predominantly inattentive subtype affected 29.7% of patients, ADHD predominantly hyperactive-impulsive was found in 5.2%, and the combined subtype in 65.1%. Overall, a significant lower Clinical Global Impression (CGI) score and mean number of DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision) symptoms by subtype were found after one year of treatment with immediate-release methylphenidate; CGI decreased from 4.51 to 1.69, symptoms of inattention from 7.90 to 4.34, symptoms of hyperactivity from 6.73 to 3.39, and combined subtype symptoms from 14.62 to 7.7. Satisfaction with immediate-release methylphenidate after one year was evaluated as &ldquo;very satisfied&rdquo; or &ldquo;satisfied&rdquo; by 86.90% of the sample; 25.75% of all patients reported at least one adverse effect. At the end of the study, 41.47% of all the patients treated with immediate-release methylphenidate were still receiving it, with a mean time of 3.80 years on therapy.Conclusion: Good efficacy and safety results were found for immediate-release methylphenidate in patients with ADHD.Keywords: attention deficit hyperactivity disorder, ADHD, pharmacologic treatment, methylphenidate, satisfactionValdiz&aacute;n-Us&oacute;n JRC&aacute;novas-Mart&iacute;nez ADe Lucas-Taracena MD&iacute;az-Atienza FEddy-Ives LSFern&aacute;ndez-Ja&eacute;n AFern&aacute;ndez-P&eacute;rez MGarc&iacute;a-Giral MGarc&iacute;a-Mag&aacute;n PGarraus-Oneca MIdiaz&aacute;bal-Alecha MAL&oacute;pez-Benito MLorenzo-Sanz GMart&iacute;nez-Ant&oacute;n JMart&iacute;nez-Granero MAMonta&ntilde;&eacute;s-Rada FMulas-Delgado FOchando-Perales GOrtega-Garc&iacute;a EPelaz-Antol&iacute;n ARamos-Quiroga JARuiz-Sanz FCVaquerizo-Madrid JYusta-Izquierdo ADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 211-218 (2013)

Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study

Ejemplares similares