A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

As part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change secretion pattern following mating, is involved in...

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Autores principales:	Sharon R Ladyman, Kirsten M Carter, Matt L Gillett, Zin Khant Aung, David R Grattan
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	prolactin running wheel pregnancy prolactin receptors medial preoptic area Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b6af943bd6e4dc180a81d3c4448ab39
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spelling	oai:doaj.org-article:8b6af943bd6e4dc180a81d3c4448ab392021-11-24T12:21:53ZA reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin10.7554/eLife.622602050-084Xe62260https://doaj.org/article/8b6af943bd6e4dc180a81d3c4448ab392021-09-01T00:00:00Zhttps://elifesciences.org/articles/62260https://doaj.org/toc/2050-084XAs part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change secretion pattern following mating, is involved in driving this suppression of physical activity levels during pregnancy. We show that prolactin can acutely suppress RWA in non-pregnant female mice, and that conditional deletion of prolactin receptors (Prlr) from either most forebrain neurons or from GABA neurons prevented the early pregnancy-induced suppression of RWA. Deletion of Prlr specifically from the medial preoptic area, a brain region associated with multiple homeostatic and behavioral roles including parental behavior, completely abolished the early pregnancy-induced suppression of RWA. As pregnancy progresses, prolactin action continues to contribute to the further suppression of RWA, although it is not the only factor involved. Our data demonstrate a key role for prolactin in suppressing voluntary physical activity during early pregnancy, highlighting a novel biological basis for reduced physical activity in pregnancy.Sharon R LadymanKirsten M CarterMatt L GillettZin Khant AungDavid R GrattaneLife Sciences Publications Ltdarticleprolactinrunning wheelpregnancyprolactin receptorsmedial preoptic areaMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prolactin running wheel pregnancy prolactin receptors medial preoptic area Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	prolactin running wheel pregnancy prolactin receptors medial preoptic area Medicine R Science Q Biology (General) QH301-705.5 Sharon R Ladyman Kirsten M Carter Matt L Gillett Zin Khant Aung David R Grattan A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
description	As part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change secretion pattern following mating, is involved in driving this suppression of physical activity levels during pregnancy. We show that prolactin can acutely suppress RWA in non-pregnant female mice, and that conditional deletion of prolactin receptors (Prlr) from either most forebrain neurons or from GABA neurons prevented the early pregnancy-induced suppression of RWA. Deletion of Prlr specifically from the medial preoptic area, a brain region associated with multiple homeostatic and behavioral roles including parental behavior, completely abolished the early pregnancy-induced suppression of RWA. As pregnancy progresses, prolactin action continues to contribute to the further suppression of RWA, although it is not the only factor involved. Our data demonstrate a key role for prolactin in suppressing voluntary physical activity during early pregnancy, highlighting a novel biological basis for reduced physical activity in pregnancy.
format	article
author	Sharon R Ladyman Kirsten M Carter Matt L Gillett Zin Khant Aung David R Grattan
author_facet	Sharon R Ladyman Kirsten M Carter Matt L Gillett Zin Khant Aung David R Grattan
author_sort	Sharon R Ladyman
title	A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
title_short	A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
title_full	A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
title_fullStr	A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
title_full_unstemmed	A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
title_sort	reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/8b6af943bd6e4dc180a81d3c4448ab39
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A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

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