Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

Grosskopf et al. report the development of a tumor inoculation method using self-assembled alginate hydrogels containing different tumorigenic molecules to reproducibly generate tumors in a subcutaneous murine tumor model. They show the impact of this improved model on the reduction of cohort size a...

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Autores principales:	Abigail K. Grosskopf, Santiago Correa, Julie Baillet, Caitlin L. Maikawa, Emily C. Gale, Ryanne A. Brown, Eric A. Appel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b6bd5be597c4cf9bd3aa23d5dc16608
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spelling	oai:doaj.org-article:8b6bd5be597c4cf9bd3aa23d5dc166082021-12-02T15:10:45ZConsistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies10.1038/s42003-021-02500-82399-3642https://doaj.org/article/8b6bd5be597c4cf9bd3aa23d5dc166082021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02500-8https://doaj.org/toc/2399-3642Grosskopf et al. report the development of a tumor inoculation method using self-assembled alginate hydrogels containing different tumorigenic molecules to reproducibly generate tumors in a subcutaneous murine tumor model. They show the impact of this improved model on the reduction of cohort size and increase in the power of the study design.Abigail K. GrosskopfSantiago CorreaJulie BailletCaitlin L. MaikawaEmily C. GaleRyanne A. BrownEric A. AppelNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Abigail K. Grosskopf Santiago Correa Julie Baillet Caitlin L. Maikawa Emily C. Gale Ryanne A. Brown Eric A. Appel Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
description	Grosskopf et al. report the development of a tumor inoculation method using self-assembled alginate hydrogels containing different tumorigenic molecules to reproducibly generate tumors in a subcutaneous murine tumor model. They show the impact of this improved model on the reduction of cohort size and increase in the power of the study design.
format	article
author	Abigail K. Grosskopf Santiago Correa Julie Baillet Caitlin L. Maikawa Emily C. Gale Ryanne A. Brown Eric A. Appel
author_facet	Abigail K. Grosskopf Santiago Correa Julie Baillet Caitlin L. Maikawa Emily C. Gale Ryanne A. Brown Eric A. Appel
author_sort	Abigail K. Grosskopf
title	Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_short	Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_full	Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_fullStr	Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_full_unstemmed	Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_sort	consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b6bd5be597c4cf9bd3aa23d5dc16608
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Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

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