Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

<h4>Objectives</h4>To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.<...

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Autores principales:	Tomas Kalincik, Manuela Vaneckova, Michaela Tyblova, Jan Krasensky, Zdenek Seidl, Eva Havrdova, Dana Horakova
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b6cc9f401264d2ea01d00856af1e3d2
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spelling	oai:doaj.org-article:8b6cc9f401264d2ea01d00856af1e3d22021-11-18T08:08:30ZVolumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.1932-620310.1371/journal.pone.0050101https://doaj.org/article/8b6cc9f401264d2ea01d00856af1e3d22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166826/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.<h4>Methods</h4>The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years.<h4>Results</h4>Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callosum cross-sectional area, higher T2 lesion volume and more contrast-enhancing lesions. Six-month decrease in corpus callosum cross-sectional area (≥ 1%) and baseline T2 lesion volume (≥ 5 cm(3)) predicted clinically definite multiple sclerosis within 2 years (hazard ratios 2.5 and 1.8, respectively). Of 22 patients fulfilling both predictive criteria, 83% reached clinically definite multiple sclerosis (hazard ratio 6.5). More relapses were associated with poorer recovery of neurological function and accelerated brain atrophy.<h4>Conclusions</h4>Neurological impairment is more permanent, brain atrophy is accelerated and focal inflammatory activity is greater in patients converting to clinically definite multiple sclerosis. Six-month corpus callosum atrophy and baseline T2 lesion volume jointly help predict individual risk of clinically definite multiple sclerosis. Early relapses contribute to permanent damage of the central nervous system.Tomas KalincikManuela VaneckovaMichaela TyblovaJan KrasenskyZdenek SeidlEva HavrdovaDana HorakovaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50101 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomas Kalincik Manuela Vaneckova Michaela Tyblova Jan Krasensky Zdenek Seidl Eva Havrdova Dana Horakova Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
description	<h4>Objectives</h4>To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.<h4>Methods</h4>The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years.<h4>Results</h4>Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callosum cross-sectional area, higher T2 lesion volume and more contrast-enhancing lesions. Six-month decrease in corpus callosum cross-sectional area (≥ 1%) and baseline T2 lesion volume (≥ 5 cm(3)) predicted clinically definite multiple sclerosis within 2 years (hazard ratios 2.5 and 1.8, respectively). Of 22 patients fulfilling both predictive criteria, 83% reached clinically definite multiple sclerosis (hazard ratio 6.5). More relapses were associated with poorer recovery of neurological function and accelerated brain atrophy.<h4>Conclusions</h4>Neurological impairment is more permanent, brain atrophy is accelerated and focal inflammatory activity is greater in patients converting to clinically definite multiple sclerosis. Six-month corpus callosum atrophy and baseline T2 lesion volume jointly help predict individual risk of clinically definite multiple sclerosis. Early relapses contribute to permanent damage of the central nervous system.
format	article
author	Tomas Kalincik Manuela Vaneckova Michaela Tyblova Jan Krasensky Zdenek Seidl Eva Havrdova Dana Horakova
author_facet	Tomas Kalincik Manuela Vaneckova Michaela Tyblova Jan Krasensky Zdenek Seidl Eva Havrdova Dana Horakova
author_sort	Tomas Kalincik
title	Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
title_short	Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
title_full	Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
title_fullStr	Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
title_full_unstemmed	Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
title_sort	volumetric mri markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8b6cc9f401264d2ea01d00856af1e3d2
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Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

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