Glucose represses dendritic cell-induced T cell responses

Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory f...

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Autores principales:	Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002
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spelling	oai:doaj.org-article:8b6f6381f79247dc8ef24920ae6d60022021-12-02T15:38:45ZGlucose represses dendritic cell-induced T cell responses10.1038/ncomms156202041-1723https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d60022017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15620https://doaj.org/toc/2041-1723Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory functions, which in turn enhance T cell effector functions in DC-T cell cocultures.Simon J. LawlessNidhi Kedia-MehtaJessica F. WallsRyan McGarrigleOrla ConveryLinda V. SinclairMaria N. NavarroJames MurrayDavid K. FinlayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon J. Lawless Nidhi Kedia-Mehta Jessica F. Walls Ryan McGarrigle Orla Convery Linda V. Sinclair Maria N. Navarro James Murray David K. Finlay Glucose represses dendritic cell-induced T cell responses
description	Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory functions, which in turn enhance T cell effector functions in DC-T cell cocultures.
format	article
author	Simon J. Lawless Nidhi Kedia-Mehta Jessica F. Walls Ryan McGarrigle Orla Convery Linda V. Sinclair Maria N. Navarro James Murray David K. Finlay
author_facet	Simon J. Lawless Nidhi Kedia-Mehta Jessica F. Walls Ryan McGarrigle Orla Convery Linda V. Sinclair Maria N. Navarro James Murray David K. Finlay
author_sort	Simon J. Lawless
title	Glucose represses dendritic cell-induced T cell responses
title_short	Glucose represses dendritic cell-induced T cell responses
title_full	Glucose represses dendritic cell-induced T cell responses
title_fullStr	Glucose represses dendritic cell-induced T cell responses
title_full_unstemmed	Glucose represses dendritic cell-induced T cell responses
title_sort	glucose represses dendritic cell-induced t cell responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002
work_keys_str_mv	AT simonjlawless glucoserepressesdendriticcellinducedtcellresponses AT nidhikediamehta glucoserepressesdendriticcellinducedtcellresponses AT jessicafwalls glucoserepressesdendriticcellinducedtcellresponses AT ryanmcgarrigle glucoserepressesdendriticcellinducedtcellresponses AT orlaconvery glucoserepressesdendriticcellinducedtcellresponses AT lindavsinclair glucoserepressesdendriticcellinducedtcellresponses AT mariannavarro glucoserepressesdendriticcellinducedtcellresponses AT jamesmurray glucoserepressesdendriticcellinducedtcellresponses AT davidkfinlay glucoserepressesdendriticcellinducedtcellresponses
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Glucose represses dendritic cell-induced T cell responses

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