AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M

Abstract Aquaglyceroporins (AQPs) allow the movement of glycerol that is required for triglyceride formation in hepatic stellate cells (HSC), as key cellular source of fibrogenesis in the liver. The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associat...

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Autores principales: Matteo Tardelli, Francesca V. Bruschi, Thierry Claudel, Veronica Moreno-Viedma, Emina Halilbasic, Fabio Marra, Merima Herac, Thomas M. Stulnig, Michael Trauner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/8b73a292eb56472ba1d21a8fd55ac455
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