TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.

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Autores principales:	Rekha Rai, Yong Chen, Ming Lei, Sandy Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b76e8537c054f68b658ac80288e929e
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spelling	oai:doaj.org-article:8b76e8537c054f68b658ac80288e929e2021-12-02T15:34:09ZTRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions10.1038/ncomms108812041-1723https://doaj.org/article/8b76e8537c054f68b658ac80288e929e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10881https://doaj.org/toc/2041-1723While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.Rekha RaiYong ChenMing LeiSandy ChangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rekha Rai Yong Chen Ming Lei Sandy Chang TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
description	While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.
format	article
author	Rekha Rai Yong Chen Ming Lei Sandy Chang
author_facet	Rekha Rai Yong Chen Ming Lei Sandy Chang
author_sort	Rekha Rai
title	TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
title_short	TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
title_full	TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
title_fullStr	TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
title_full_unstemmed	TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
title_sort	trf2-rap1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8b76e8537c054f68b658ac80288e929e
work_keys_str_mv	AT rekharai trf2rap1isrequiredtoprotecttelomeresfromengaginginhomologousrecombinationmediateddeletionsandfusions AT yongchen trf2rap1isrequiredtoprotecttelomeresfromengaginginhomologousrecombinationmediateddeletionsandfusions AT minglei trf2rap1isrequiredtoprotecttelomeresfromengaginginhomologousrecombinationmediateddeletionsandfusions AT sandychang trf2rap1isrequiredtoprotecttelomeresfromengaginginhomologousrecombinationmediateddeletionsandfusions
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TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

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