TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.

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Autores principales: Rekha Rai, Yong Chen, Ming Lei, Sandy Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/8b76e8537c054f68b658ac80288e929e
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