YAP determines the cell fate of injured mouse hepatocytes in vivo

YAP determines the cell fate of injured mouse hepatocytes in vivo

Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis...

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Autores principales: Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/8b7ca4029c1c488caa7b2fb3bdb9af8f
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spelling oai:doaj.org-article:8b7ca4029c1c488caa7b2fb3bdb9af8f2021-12-02T15:38:39ZYAP determines the cell fate of injured mouse hepatocytes in vivo10.1038/ncomms160172041-1723https://doaj.org/article/8b7ca4029c1c488caa7b2fb3bdb9af8f2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16017https://doaj.org/toc/2041-1723Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.Norio MiyamuraShoji HataTohru ItohMinoru TanakaMiki NishioMichiko ItohYoshihiro OgawaShuji TeraiIsao SakaidaAkira SuzukiAtsushi MiyajimaHiroshi NishinaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Norio Miyamura
Shoji Hata
Tohru Itoh
Minoru Tanaka
Miki Nishio
Michiko Itoh
Yoshihiro Ogawa
Shuji Terai
Isao Sakaida
Akira Suzuki
Atsushi Miyajima
Hiroshi Nishina
YAP determines the cell fate of injured mouse hepatocytes in vivo
description Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.
format article
author Norio Miyamura
Shoji Hata
Tohru Itoh
Minoru Tanaka
Miki Nishio
Michiko Itoh
Yoshihiro Ogawa
Shuji Terai
Isao Sakaida
Akira Suzuki
Atsushi Miyajima
Hiroshi Nishina
author_facet Norio Miyamura
Shoji Hata
Tohru Itoh
Minoru Tanaka
Miki Nishio
Michiko Itoh
Yoshihiro Ogawa
Shuji Terai
Isao Sakaida
Akira Suzuki
Atsushi Miyajima
Hiroshi Nishina
author_sort Norio Miyamura
title YAP determines the cell fate of injured mouse hepatocytes in vivo
title_short YAP determines the cell fate of injured mouse hepatocytes in vivo
title_full YAP determines the cell fate of injured mouse hepatocytes in vivo
title_fullStr YAP determines the cell fate of injured mouse hepatocytes in vivo
title_full_unstemmed YAP determines the cell fate of injured mouse hepatocytes in vivo
title_sort yap determines the cell fate of injured mouse hepatocytes in vivo
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8b7ca4029c1c488caa7b2fb3bdb9af8f
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