Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review

Drug-induced interstitial lung disease (DILD) has been occasionally reported with various causative drugs. In the context of breast cancer, anthracycline infrequently causes pulmonary adverse events. We report a 67-year-old woman with cT2N0M0 triple-negative breast cancer who received neoadjuvant ch...

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Autores principales:	Hideko Hoshina, Hiroyuki Takei
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	drug-induced interstitial lung disease interstitial pneumonia breast cancer anthracycline prednisolone Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8b7db9562aaf4b3c85a16ae8741a0fcc
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spelling	oai:doaj.org-article:8b7db9562aaf4b3c85a16ae8741a0fcc2021-12-02T12:40:23ZDrug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review1662-657510.1159/000520126https://doaj.org/article/8b7db9562aaf4b3c85a16ae8741a0fcc2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520126https://doaj.org/toc/1662-6575Drug-induced interstitial lung disease (DILD) has been occasionally reported with various causative drugs. In the context of breast cancer, anthracycline infrequently causes pulmonary adverse events. We report a 67-year-old woman with cT2N0M0 triple-negative breast cancer who received neoadjuvant chemotherapy with anthracycline-combined chemotherapy with pegfilgrastim. She developed fever, cough, and shortness of breath after 21 days of the scheduled fourth cycle of anthracycline. Computed tomography revealed drug-induced interstitial pneumonia. Prednisolone (1 mg/kg) was administrated and gradually decreased. Thereby, interstitial pneumonia quickly improved. Partial resection of the left breast and sentinel lymph node biopsy were performed, and we diagnosed ypT1bN0. The patient received 4 cycles of taxane and hypofractional radiotherapy and survived without any recurrences over the following 37 months. We report a rare case of DILD due to anthracycline-combined chemotherapy. Twenty-five cases of DILD with breast cancer after administration of anthracycline have been reported so far. However, 14 cases occurred during taxane. Most of the cases had remission by steroid treatment. The patients with respiratory symptoms during chemotherapy should be suspicious of not only infection but also DILD.Hideko HoshinaHiroyuki TakeiKarger Publishersarticledrug-induced interstitial lung diseaseinterstitial pneumoniabreast canceranthracyclineprednisoloneNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1671-1676 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-induced interstitial lung disease interstitial pneumonia breast cancer anthracycline prednisolone Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	drug-induced interstitial lung disease interstitial pneumonia breast cancer anthracycline prednisolone Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hideko Hoshina Hiroyuki Takei Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
description	Drug-induced interstitial lung disease (DILD) has been occasionally reported with various causative drugs. In the context of breast cancer, anthracycline infrequently causes pulmonary adverse events. We report a 67-year-old woman with cT2N0M0 triple-negative breast cancer who received neoadjuvant chemotherapy with anthracycline-combined chemotherapy with pegfilgrastim. She developed fever, cough, and shortness of breath after 21 days of the scheduled fourth cycle of anthracycline. Computed tomography revealed drug-induced interstitial pneumonia. Prednisolone (1 mg/kg) was administrated and gradually decreased. Thereby, interstitial pneumonia quickly improved. Partial resection of the left breast and sentinel lymph node biopsy were performed, and we diagnosed ypT1bN0. The patient received 4 cycles of taxane and hypofractional radiotherapy and survived without any recurrences over the following 37 months. We report a rare case of DILD due to anthracycline-combined chemotherapy. Twenty-five cases of DILD with breast cancer after administration of anthracycline have been reported so far. However, 14 cases occurred during taxane. Most of the cases had remission by steroid treatment. The patients with respiratory symptoms during chemotherapy should be suspicious of not only infection but also DILD.
format	article
author	Hideko Hoshina Hiroyuki Takei
author_facet	Hideko Hoshina Hiroyuki Takei
author_sort	Hideko Hoshina
title	Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
title_short	Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
title_full	Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
title_fullStr	Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
title_full_unstemmed	Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review
title_sort	drug-induced interstitial lung disease after anthracycline-combined chemotherapy for breast cancer: a case report and literature review
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/8b7db9562aaf4b3c85a16ae8741a0fcc
work_keys_str_mv	AT hidekohoshina druginducedinterstitiallungdiseaseafteranthracyclinecombinedchemotherapyforbreastcanceracasereportandliteraturereview AT hiroyukitakei druginducedinterstitiallungdiseaseafteranthracyclinecombinedchemotherapyforbreastcanceracasereportandliteraturereview
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Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review

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