Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

In recent years, human gut microbiota have become one of the most promising areas of microorganism research; meanwhile, the inter-relation between the gut microbiota and various human diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central...

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Autores principales:	Peilin Sun, Lei Su, Hua Zhu, Xue Li, Yaxi Guo, Xiaopeng Du, Ling Zhang, Chuan Qin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gut microbiota gut–brain axis neurodegenerative diseases Alzheimer’s disease Parkinson’s disease mechanism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b7ddbce834f42a4a84864b8c64bde0d
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spelling	oai:doaj.org-article:8b7ddbce834f42a4a84864b8c64bde0d2021-11-25T18:24:49ZGut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease10.3390/microorganisms91122812076-2607https://doaj.org/article/8b7ddbce834f42a4a84864b8c64bde0d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2281https://doaj.org/toc/2076-2607In recent years, human gut microbiota have become one of the most promising areas of microorganism research; meanwhile, the inter-relation between the gut microbiota and various human diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includes neuronal, immune-mediated and metabolite-mediated pathways. Additionally, recent progress from both preclinical and clinical studies indicated that gut microbiota play a pivotal role in gut–brain interactions, whereas the imbalance of the gut microbiota composition may be associated with the pathogenesis of neurological diseases (particularly neurodegenerative diseases), the underlying mechanism of which is insufficiently studied. This review aims to highlight the relationship between gut microbiota and neurodegenerative diseases, and to contribute to our understanding of the function of gut microbiota in neurodegeneration, as well as their relevant mechanisms. Furthermore, we also discuss the current application and future prospects of microbiota-associated therapy, including probiotics and fecal microbiota transplantation (FMT), potentially shedding new light on the research of neurodegeneration.Peilin SunLei SuHua ZhuXue LiYaxi GuoXiaopeng DuLing ZhangChuan QinMDPI AGarticlegut microbiotagut–brain axisneurodegenerative diseasesAlzheimer’s diseaseParkinson’s diseasemechanismBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2281, p 2281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota gut–brain axis neurodegenerative diseases Alzheimer’s disease Parkinson’s disease mechanism Biology (General) QH301-705.5
spellingShingle	gut microbiota gut–brain axis neurodegenerative diseases Alzheimer’s disease Parkinson’s disease mechanism Biology (General) QH301-705.5 Peilin Sun Lei Su Hua Zhu Xue Li Yaxi Guo Xiaopeng Du Ling Zhang Chuan Qin Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
description	In recent years, human gut microbiota have become one of the most promising areas of microorganism research; meanwhile, the inter-relation between the gut microbiota and various human diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includes neuronal, immune-mediated and metabolite-mediated pathways. Additionally, recent progress from both preclinical and clinical studies indicated that gut microbiota play a pivotal role in gut–brain interactions, whereas the imbalance of the gut microbiota composition may be associated with the pathogenesis of neurological diseases (particularly neurodegenerative diseases), the underlying mechanism of which is insufficiently studied. This review aims to highlight the relationship between gut microbiota and neurodegenerative diseases, and to contribute to our understanding of the function of gut microbiota in neurodegeneration, as well as their relevant mechanisms. Furthermore, we also discuss the current application and future prospects of microbiota-associated therapy, including probiotics and fecal microbiota transplantation (FMT), potentially shedding new light on the research of neurodegeneration.
format	article
author	Peilin Sun Lei Su Hua Zhu Xue Li Yaxi Guo Xiaopeng Du Ling Zhang Chuan Qin
author_facet	Peilin Sun Lei Su Hua Zhu Xue Li Yaxi Guo Xiaopeng Du Ling Zhang Chuan Qin
author_sort	Peilin Sun
title	Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
title_short	Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
title_full	Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
title_fullStr	Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
title_full_unstemmed	Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
title_sort	gut microbiota regulation and their implication in the development of neurodegenerative disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8b7ddbce834f42a4a84864b8c64bde0d
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Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

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